Managing Thyroid Hormone Levels: From Hypothyroidism to Hyperthyroidism - Internal Medicine

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Hypothyroidism to Hyperthyroidism


Hello Doctor, I was diagnosed with anti-microsomal antibodies at a titer of 1:1600 in 2009, and my T4 and TSH levels were normal, indicating Hashimoto's thyroiditis (hypothyroidism).
From 2009 to June 2021, I took Eltroxin 50 mcg daily, but I often forgot to take it.
My T4 and TSH levels remained within the normal range.
However, in the past month, I have been more diligent about taking my medication every day, yet I have been feeling unwell, experiencing weight loss, lack of appetite, shortness of breath, and weakness.
My recent blood test results showed T4 at 1.971 (normal range 0.7-1.8) and TSH at 0.21 (normal range 0.25-4).
My doctor said I am overmedicated and advised me to take the medication only 6 days a week.
I asked the doctor if I should stop taking the medication for a few days before resuming, but the doctor said that because I have hypothyroidism, I cannot stop the medication.
I also mentioned to my doctor that in the past, I often took the medication for less than 10 days a month, and my levels were still normal! The doctor still insists I take it 6 days a week, and I am worried that this will lead to continued hyperthyroidism.
What is your opinion, Doctor? At the same time, I have a slight pain in a specific spot in my throat, and when I swallow saliva, it feels like there is something stuck, accompanied by a cartilage-like sound.
I saw an ENT specialist, who diagnosed me with chronic pharyngitis.
I have been on medication for 7 days with no improvement.
I wonder if this is related to my thyroid condition.
Thank you, Doctor.

Wei Li, 60~69 year old female. Ask Date: 2021/07/08

Dr. Lin Jianliang reply Internal Medicine


Hello: Since everyone's situation is different, some people resume medication after stopping or reduce the dosage.
It depends on individual circumstances for adjustments.
Regarding the other issue, it requires an in-person evaluation to provide a response, so I cannot address it here.

Reply Date: 2021/07/08

More Info


Managing thyroid hormone levels is crucial for maintaining overall health, especially for individuals diagnosed with conditions like Hashimoto's thyroiditis, which is an autoimmune disorder that often leads to hypothyroidism. Your situation, where you have been on levothyroxine (Eltroxin) for many years, indicates that you have been managing your thyroid hormone levels to keep them within the normal range. However, recent changes in your symptoms and lab results suggest that your current dosage may need to be adjusted.

From your description, it appears that you have been experiencing symptoms consistent with hyperthyroidism, such as weight loss, lack of appetite, shortness of breath, and weakness. Your recent lab results show elevated T4 levels and suppressed TSH levels, which indicate that your thyroid hormone levels are indeed higher than normal. This can happen if the dosage of levothyroxine is too high, leading to a condition known as iatrogenic hyperthyroidism.

Your doctor’s recommendation to reduce your dosage to six days a week is a common approach to managing this situation. It is important to follow your doctor's advice and not to stop the medication entirely, as doing so could lead to a rebound effect, causing your thyroid hormone levels to drop too low, which can result in symptoms of hypothyroidism. Instead, the goal is to find a balance where your T4 and TSH levels remain within the normal range without causing hyperthyroid symptoms.

Regarding your concerns about the chronic throat pain and the sensation of something stuck in your throat, it is possible that these symptoms are related to your thyroid condition, especially if there is any swelling or enlargement of the thyroid gland (goiter). However, it is also possible that these symptoms are due to chronic pharyngitis or another unrelated condition. Since you have already consulted an ENT specialist, it would be wise to follow up with them if your symptoms persist despite treatment.

In terms of dietary considerations, while managing thyroid conditions, it is generally advisable to avoid excessive iodine intake, as it can affect thyroid function. Foods rich in iodine, such as seaweed, should be consumed in moderation. Additionally, maintaining a balanced diet that supports overall health is essential.

In summary, it is crucial to work closely with your healthcare provider to adjust your medication dosage appropriately. Regular monitoring of your thyroid hormone levels will help ensure that you remain within the desired range. If your symptoms persist or worsen, further evaluation may be necessary to rule out other underlying conditions. Always communicate openly with your healthcare provider about any new symptoms or concerns you may have, as this will help them tailor your treatment plan to your specific needs.

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