Recurrent Arthritis: Causes, Diagnosis, and Management - Internal Medicine

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Recurrent arthritis (migratory arthritis)


Hello, Doctor:
For the past six months, I have been experiencing persistent pain in my shoulders and limbs.
Initially, I consulted an orthopedic specialist who performed an X-ray but found no issues.
The doctor prescribed pain relievers and suggested considering physical therapy, which I did not pursue.
Subsequently, I visited a neurosurgeon who, after taking my history, noted that the pain was localized to the joints and indicated that it might not be a neurological issue, recommending that I see a rheumatologist.
After consulting the rheumatologist and undergoing several tests, an ultrasound revealed mild inflammation in multiple joints.
Blood tests showed normal inflammatory markers, negative ANA, negative CCP antibodies, but a mildly positive RF factor.
The doctor informed me that this does not qualify as rheumatoid arthritis but rather as migratory arthritis or recurrent arthritis.
I was prescribed quinine and pain relievers.
I would like to ask the following:
1.
Is recurrent arthritis considered an autoimmune disease? Are the intermittent and unpredictable joint pains and swelling I experience due to my immune system attacking itself, or could they be attributed to other factors? (The doctor did not explain why I frequently have pain in multiple joints.) I also feel that I have not overused my limbs or engaged in excessive exercise.
2.
If this condition is indeed classified as an autoimmune disease, what is the difference between this type of arthritis and rheumatoid arthritis?
3.
Is this condition a lifelong disease? Is there a possibility that it could progress to rheumatoid arthritis? Are there any methods to prevent worsening or to eliminate it?
Thank you, Doctor!

Evie, 30~39 year old female. Ask Date: 2021/07/08

Dr. Gao Jiankai reply Internal Medicine


Hello, thank you for your question.
Here are my responses:
1.
Is recurrent arthritis considered an autoimmune disease? The joint pain and swelling that I experience intermittently—are they caused by my immune system attacking itself, or are there other factors involved? (The doctor did not explain why I often have pain in multiple joints.) --> Yes, it is also a mild immune dysfunction.
These symptoms indeed arise from the immune system attacking the body's own tissues, but the severity is relatively mild.
2.
If this is also classified as an autoimmune disease, what is the difference between this type of arthritis and rheumatoid arthritis? --> It falls under mild immune dysfunction, and the symptoms along with blood test results cannot be categorized into any specific rheumatic disease.
It may continue to recur in this manner or develop into a defined rheumatic disease, including rheumatoid arthritis or systemic lupus erythematosus.
3.
Is this condition a lifelong disease? Could it progress to rheumatoid arthritis? Are there any ways to prevent worsening or to eliminate it? --> As mentioned in question 2, studies have shown that approximately 30-40% of individuals with recurrent rheumatic symptoms may evolve into rheumatoid arthritis after 20 years of follow-up.
However, if the symptoms are mild and infrequent, we often recommend taking anti-inflammatory pain relievers only during flare-ups.
If flare-ups are frequent or if ultrasound shows signs of localized inflammation, immunomodulatory medications, such as quinine, may be added to treat it as mild rheumatoid arthritis.
Since recurrent rheumatic symptoms also represent a mild immune dysfunction, and immune function is very sensitive to lifestyle, I often advise patients to maintain a regular routine and engage in regular exercise, as this may help soothe immune function and potentially reduce the frequency of pain episodes.

For your reference, this is from the Allergy, Immunology, and Rheumatology Department of Changhua Hospital, Ministry of Health and Welfare.
We care about your health.

Reply Date: 2021/07/08

More Info


Recurrent arthritis, particularly in the context of your symptoms and the diagnosis of palindromic rheumatism or recurrent arthritis, can indeed be a complex condition. Let's break down your questions and concerns regarding this condition, its causes, diagnosis, and management.

1. Is recurrent arthritis considered an autoimmune disease?
Recurrent arthritis, particularly palindromic rheumatism, is often classified as an autoimmune or autoinflammatory condition. In autoimmune diseases, the immune system mistakenly attacks the body's own tissues, leading to inflammation and pain in the joints. In your case, the intermittent joint pain and swelling could be due to your immune system's dysregulation, which may not necessarily be a full-blown autoimmune disease like rheumatoid arthritis but still indicates an underlying immune response. The fact that your RF (rheumatoid factor) is slightly positive suggests that there may be some immune activity, but it is not definitive for rheumatoid arthritis.

2. What is the difference between this type of arthritis and rheumatoid arthritis?
The primary difference lies in the chronicity and the pattern of symptoms. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation, joint damage, and systemic symptoms. It typically affects multiple joints symmetrically and can lead to significant joint deformities over time. In contrast, palindromic rheumatism is characterized by episodes of arthritis that can resolve completely between attacks, and it does not usually cause permanent joint damage. However, there is a risk that palindromic rheumatism can evolve into RA in some patients, which is why monitoring and follow-up with a rheumatologist are essential.

3. Is this condition lifelong, and can it progress to rheumatoid arthritis?
Recurrent arthritis can indeed be a long-term condition, but its course can vary significantly among individuals. Some patients may experience only a few episodes, while others may have frequent recurrences. There is a possibility that palindromic rheumatism can progress to rheumatoid arthritis, as you mentioned. The risk factors for this progression include the presence of certain antibodies and the frequency and severity of the episodes. Regular follow-ups with your rheumatologist can help monitor your condition and adjust treatment as necessary.

4. How can one prevent worsening of the condition or achieve remission?
While there is no definitive cure for recurrent arthritis, several strategies can help manage symptoms and potentially reduce the frequency of flare-ups. These include:
- Medication: Nonsteroidal anti-inflammatory drugs (NSAIDs) can help manage pain and inflammation during flare-ups. Disease-modifying antirheumatic drugs (DMARDs) may be considered if your symptoms worsen or if there is a risk of progression to RA.

- Lifestyle Modifications: Regular, low-impact exercise can help maintain joint function and reduce stiffness. Physical therapy may also be beneficial.

- Diet and Nutrition: Some patients find relief through anti-inflammatory diets, which emphasize whole foods, omega-3 fatty acids, and antioxidants.

- Stress Management: Stress can exacerbate symptoms, so practices such as mindfulness, yoga, or meditation may be helpful.

In conclusion, while recurrent arthritis can be a challenging condition, understanding its nature and maintaining open communication with your healthcare provider can lead to effective management strategies. Regular monitoring and a proactive approach to treatment can help you maintain a good quality of life. If you have further concerns or if your symptoms change, seeking a second opinion or additional evaluations may provide you with more clarity and options.

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