Elevated PSA Levels: Concerns and Next Steps for Men - Urology

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Elevated PSA levels?


Hello Dr.
Du: I have been troubled by a few questions, and I would like to ask for your assistance:
1.
I am 30 years old.
Since 2013, my annual health check-up reports have shown PSA levels consistently in the range of 3 to 4.
In 2020-2021, I had closer monitoring with three tests, and the results were still around 3.
Later, I underwent a digital rectal exam and MRI at Taipei Medical University, both of which did not reveal any abnormalities.
However, I am still very concerned about my consistently elevated PSA levels and whether this could indicate prostate cancer or benign prostatic hyperplasia.
If I want to confirm these conditions, what additional tests can I undergo, or should I just continue to monitor my PSA levels regularly?
2.
Additionally, I would like to ask about my urination.
After urinating, I often experience post-void dribbling and have to push on my genital area to ensure I empty my bladder completely.
However, sometimes after putting on my underwear, a few drops still come out (I do not have issues with nocturia or frequency).
Is this normal, or could it be a sign of benign prostatic hyperplasia or another issue? Thank you, doctor.

ken, 30~39 year old female. Ask Date: 2021/07/10

Dr. Du Shixi reply Urology


Hello: 1.
I am 30 years old.
Since 2013, my annual health check-up reports have shown a PSA level in the range of 3 to 4.
From 2020 to 2021, I had closer monitoring with three tests, and the levels were still around 3.
Later, I underwent a digital rectal exam and MRI at National Taiwan University Hospital, both of which did not reveal any abnormalities.
However, I am still very concerned about the consistently elevated PSA levels and whether I might have prostate cancer or benign prostatic hyperplasia.
If I want to confirm these two conditions, what additional tests can I undergo, or should I just continue to monitor my PSA levels regularly? --> Regular check-ups, digital rectal exam, and MRI have already been performed.
2.
Additionally, I would like to ask about my urination.
After urinating, I sometimes need to squeeze my genital area to ensure that my bladder is completely empty, but occasionally a few drops still come out after I put my underwear back on (I do not have issues with nocturia or frequent urination).
Is this normal, or could it indicate benign prostatic hyperplasia or another issue? --> This is normal.
It may be beneficial to perform a urinalysis.
Pay attention to your lifestyle, drink plenty of water, maintain a light diet, and exercise moderately.
Wishing you good health.

Reply Date: 2021/07/10

More Info


Elevated PSA (Prostate-Specific Antigen) levels can be a source of concern for many men, particularly when they are consistently above the normal range. As a 30-year-old male with a history of PSA levels fluctuating between the low 3s and 4s over several years, it is understandable that you may feel anxious about the possibility of prostate cancer or benign prostatic hyperplasia (BPH). Let's address your questions and provide some insights into the management of elevated PSA levels.

1. Understanding Elevated PSA Levels: PSA is a protein produced by both normal and malignant cells of the prostate gland. While a PSA level above 4.0 ng/mL is often considered elevated, it is important to note that PSA levels can be influenced by various factors, including age, race, prostate size, and even recent activities such as sexual intercourse or vigorous exercise. In younger men, like yourself, a PSA level consistently in the 3s or 4s may not necessarily indicate cancer, especially if other diagnostic tests, such as digital rectal exams (DRE) and MRI, have not revealed any abnormalities.

Given your history of elevated PSA levels, it is crucial to continue monitoring your PSA levels regularly, as advised by your healthcare provider. If you are concerned about the potential for prostate cancer or BPH, additional tests may be warranted. These could include:
- Free PSA Test: This test measures the proportion of free PSA (not bound to proteins) in the blood. A lower percentage of free PSA can indicate a higher risk of prostate cancer.

- Prostate Biopsy: If your PSA levels continue to rise or if there are other concerning signs, a biopsy may be necessary to definitively rule out cancer.

- Transrectal Ultrasound (TRUS): This imaging test can help visualize the prostate and may assist in guiding a biopsy if needed.

2. Post-Urination Dribbling: The experience of dribbling after urination, especially if you feel the need to push or squeeze the genital area to fully empty the bladder, can be a common issue among men. This may not necessarily indicate a serious problem, but it can be associated with several factors:
- Prostate Health: Conditions like BPH can lead to urinary symptoms, including dribbling. However, since you do not report other symptoms like frequent urination or nocturia, this may not be the primary concern.

- Pelvic Floor Muscle Tone: Weakness in the pelvic floor muscles can lead to difficulties in controlling urination. Strengthening these muscles through pelvic floor exercises (Kegel exercises) may help improve control.

- Bladder Function: Sometimes, the bladder may not fully empty, leading to residual urine that can cause dribbling. A urodynamic study can assess bladder function and help identify any underlying issues.

In summary, while elevated PSA levels can be concerning, they are not definitive for prostate cancer, especially in younger men without other risk factors or symptoms. Regular monitoring and open communication with your healthcare provider are essential. If you continue to have concerns about your PSA levels or urinary symptoms, consider discussing further diagnostic options and potential referrals to specialists, such as a urologist. Remember, maintaining a healthy lifestyle, including a balanced diet and regular exercise, can also contribute positively to prostate health.

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