Unexplained Urinary Pain: Causes, Tests, and Treatment Options - Urology

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Unexplained urinary pain?


Hello Doctor, regarding my previous inquiry about recurrent urinary tract infections, I later followed up with my gynecologist, who indicated that my last three urine tests were normal and showed no signs of infection.
I continue to maintain cleanliness and take cranberry probiotics; however, I still experience occasional pain during urination, which is very distressing.
Sometimes I feel a sharp pain at the urethral opening after urination, and other times during urination itself.
The gynecologist mentioned that it could be a urethral diverticulum, which pressed against my urethra, causing only slight discomfort without pain.
The doctor said it appeared normal; possible causes could be a diverticulum, stones, or a very mild urinary tract infection.
However, due to my low immunity, my white blood cell count did not increase.
I was advised to see a urologist for further evaluation and was prescribed pain relievers and diuretics, but no antibiotics since there was no bacterial infection and the urine tests were normal.
Previously, at another urology clinic, the doctor indicated that the absence of hematuria ruled out stones and that there were no results from the bacterial culture at that time, so the gynecologist did not perform a post-catheterization culture this time.

1.
What tests should I consider when I visit the urologist?
2.
Occasionally, I experience lower back pain, but I'm unsure if it's muscular or related to my kidneys.
Could this be indicative of nephritis or stones?
3.
Since I usually do not have hematuria (or the doctor did not specifically inform me), does urinary tract stones always present with hematuria?
4.
Besides the conditions mentioned by the gynecologist, are there other possible causes for unexplained pain during urination?
Thank you, Doctor, and I apologize for the inconvenience!

Miao Mi, 20~29 year old female. Ask Date: 2021/07/13

Dr. Du Shixi reply Urology


Hello; 1.
What tests should I undergo when visiting a urologist? --> Generally, a urinalysis, X-ray, and medication may be recommended.
2.
Sometimes I experience lower back pain, but I'm not sure if it's muscular pain or related to the kidneys.
Could this be a sign of kidney inflammation or stones? --> An X-ray and ultrasound examination are needed; however, if the urinalysis is normal, the likelihood of having stones is very low.
3.
Since I usually do not have hematuria (or the doctor hasn't specifically mentioned it), does urinary stone disease always present with blood in the urine? --> Symptoms may include some degree of hematuria.
4.
Besides the conditions mentioned by the gynecologist, are there other possible causes for unexplained painful urination? --> It is unclear if sexual activity may have an impact.
Wishing you good health.

Reply Date: 2021/07/13

More Info


Unexplained urinary pain can be a frustrating and distressing experience, especially when multiple medical evaluations yield no clear diagnosis. Based on your description, it seems you have undergone several tests and consultations with both urologists and gynecologists, yet the source of your pain remains elusive. Let's address your questions systematically.

1. Recommended Tests in Urology: Given your ongoing symptoms and the previous normal urine tests, it may be beneficial to consider additional diagnostic evaluations. A urologist might recommend:
- Cystoscopy: This procedure allows the doctor to look directly into the bladder and urethra using a thin tube with a camera. It can help identify any abnormalities such as strictures, lesions, or bladder stones.

- Ultrasound or CT scan: These imaging tests can help visualize the urinary tract and identify any structural issues, such as stones or cysts that may not have been detected in previous evaluations.

- Urodynamic studies: If your urologist suspects functional issues with bladder storage or emptying, these tests can assess how well your bladder and urethra are functioning.

- Urine culture after catheterization: If there is suspicion of a urinary tract infection (UTI) that standard tests have missed, a culture from a catheterized sample may yield different results.

2. Lower Back Pain and Kidney Issues: The occasional lower back pain you experience could be related to muscle strain, especially if it coincides with physical activity or prolonged sitting. However, it could also indicate kidney issues, such as a kidney stone or even a mild infection. If the pain is persistent or worsening, it would be wise to discuss this with your urologist, who may suggest imaging studies to rule out any renal pathology.

3. Blood in Urine and Kidney Stones: While blood in the urine (hematuria) is a common sign of kidney stones, it is not always present. Some stones may not cause bleeding, especially if they are small or if they are located in areas that do not irritate the urinary tract lining. Therefore, the absence of hematuria does not definitively rule out the presence of stones.

4. Other Possible Causes of Urinary Pain: Beyond the conditions already mentioned, unexplained urinary pain can arise from several other factors:
- Interstitial Cystitis (IC): A chronic condition characterized by bladder pressure, bladder pain, and sometimes pelvic pain, which can lead to frequent urination and discomfort.

- Urethral Syndrome: This condition can cause symptoms similar to a UTI without the presence of bacteria, often linked to stress or irritation.

- Pelvic Floor Dysfunction: Issues with the pelvic floor muscles can lead to pain during urination and may require physical therapy for management.

- Nerve-related issues: Conditions like pudendal neuralgia can cause pain in the pelvic region, including during urination.

In conclusion, it is essential to maintain open communication with your healthcare providers. When you visit the urologist, express your ongoing symptoms clearly and inquire about the tests mentioned above. It is also beneficial to keep a symptom diary, noting when the pain occurs, its intensity, and any associated activities or dietary factors. This information can help your doctor make a more informed diagnosis. Don't hesitate to advocate for yourself and seek further evaluations if you feel your concerns are not being addressed adequately. Your comfort and health are paramount, and persistent symptoms warrant thorough investigation.

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