Drug Reactions: When to Seek Medical Attention - Internal Medicine

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Drug reactions


Hello Dr.
Wu, last night at 9:30 PM, I took one tablet of Pei Nian (a light orange round tablet) because my face was a bit allergic.
After taking it, I felt very drowsy one hour later and slept for 8 hours.
Upon waking up, I felt dizzy and unsteady while walking.
After lunch, I still felt very sleepy and was unable to concentrate on work all afternoon and evening, remaining in a state of drowsiness and unable to work due to heavy sleepiness.
This is the first time I have encountered such a situation.
Is this normal, or do I need to go to the hospital for a check-up in a specific department?

Mei Chen, 40~49 year old female. Ask Date: 2021/07/16

Dr. Wu Jiyu reply Internal Medicine


Pyrilamine is an antihistamine, and one of its most common side effects is drowsiness.
The duration of this drowsiness can vary from person to person; some individuals may experience it for an entire day.
Therefore, it is not advisable to engage in activities that require mental alertness, such as driving a car or operating other precision machinery, while taking this medication.
We recommend that the next time you experience allergies and need to take medication, you discuss your history of drowsiness caused by pyrilamine with your physician for their reference.
Thank you for your inquiry, and the Nephrology Department of Changhua Hospital cares about your well-being.

Reply Date: 2021/07/16

More Info


When it comes to understanding drug reactions, it's crucial to recognize the signs that warrant medical attention. Based on your description, it seems you experienced significant drowsiness and dizziness after taking a medication for an allergic reaction. This situation raises several important considerations regarding drug reactions, their timing, and when to seek medical help.

Firstly, the medication you took, which appears to be an antihistamine (likely a sedating one), can indeed cause drowsiness as a common side effect. Antihistamines work by blocking histamine receptors in the body, which helps alleviate allergy symptoms. However, many first-generation antihistamines, such as diphenhydramine (Benadryl), are known for their sedative properties. This means that while they can effectively reduce allergic reactions, they can also lead to significant drowsiness, dizziness, and impaired concentration, especially in individuals who may be more sensitive to these effects.

In your case, the onset of drowsiness one hour after taking the medication, followed by prolonged sleepiness and difficulty concentrating the next day, suggests that the drug's sedative effects were pronounced. While it is not uncommon for individuals to experience such reactions, the severity and duration of your symptoms are noteworthy. Here are some key points to consider:
1. Severity of Symptoms: If the drowsiness is so severe that it interferes with your ability to perform daily activities or work, this is a sign that you should seek medical attention. It is essential to communicate these symptoms to a healthcare provider, as they may need to evaluate whether the medication is appropriate for you or if an alternative treatment is necessary.

2. Duration of Symptoms: If the drowsiness persists beyond a day or two, or if you experience additional symptoms such as confusion, difficulty breathing, or swelling, you should seek immediate medical attention. These could be signs of a more serious reaction or an allergic response that requires intervention.

3. Underlying Conditions: If you have any pre-existing conditions, such as liver or kidney issues, or if you are taking other medications that could interact with the antihistamine, it is crucial to inform your healthcare provider. They may need to adjust your treatment plan accordingly.

4. Consulting a Healthcare Provider: If you decide to seek medical attention, consider visiting a primary care physician or an allergist. They can assess your symptoms, review your medication history, and determine if further testing or a change in medication is necessary. Additionally, they can provide guidance on managing allergic reactions and suggest alternative medications that may have fewer sedative effects.

5. Monitoring Future Reactions: It is also advisable to keep a record of any medications you take and any reactions you experience. This information can be invaluable for healthcare providers in understanding your sensitivities and tailoring your treatment plan.

In summary, while drowsiness can be a common side effect of antihistamines, the extent and duration of your symptoms warrant careful consideration. If your symptoms are affecting your daily life or if they persist, seeking medical attention is a prudent step. Always communicate openly with your healthcare provider about any adverse reactions you experience, as this will help ensure your safety and well-being in future treatments.

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