Shingles: Misdiagnosis and Treatment Challenges - Dermatology

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Suspected shingles?


Hello doctor, I would like to ask if giving the wrong medication for suspected shingles would have an impact.
I previously had shingles on my chest, and this time it occurred on the left side of my anal area.
Initially, I experienced redness, itching, and pain, and I relied on pain relief and anti-inflammatory medications to manage the symptoms.
By night, I was unable to sleep as the pain and itching persisted despite using topical treatments.
I took photos of the lesions, which appeared to be ulcerated, and I may have accidentally ruptured some blisters.
The pain was so intense that I couldn't sleep, so I saw a doctor the next day.
The clinic suspected shingles, but they dismissed it due to my incorrect description of the symptoms.
Since I initially used pain relief and anti-inflammatory medications and felt no pain or itching after applying them, I thought I was better.
Ultimately, the doctor prescribed antibiotics, which improved the symptoms and the lesions, but once the antibiotics were stopped, the redness, swelling, and sharp pain returned.
I have taken antibiotics intermittently four times based on the diagnosis.
Currently, the skin around my anal area is red and itchy, and even my labia are completely red and painful.
After seeing a dermatologist, I was prescribed antibiotics and pain relief for itching, while the gynecologist provided a similar topical anesthetic for pain relief.
Using the dermatologist's medication along with the gynecologist's ointment seems ineffective.
I wake up in pain every 2-3 hours at night and have to reapply the ointment.
The clinic doctors want to see blisters to confirm shingles.
Is there another way to confirm the diagnosis? Should I go to a major hospital for blood tests?

Liu, 30~39 year old female. Ask Date: 2021/07/21

Dr. Wu Yuxin reply Dermatology


Without actually seeing the lesion, it is impossible to determine the issue.
If it is very concerning, please seek medical attention as soon as possible.
Only after an examination can the problem be identified and addressed.

Reply Date: 2021/07/21

More Info


Understanding shingles, or herpes zoster, is crucial for effective diagnosis and treatment. Shingles is caused by the reactivation of the varicella-zoster virus, which remains dormant in the body after a person has had chickenpox. It typically presents as a painful rash that can occur anywhere on the body, but it often follows a dermatomal pattern, meaning it affects a specific area of skin supplied by a single spinal nerve.

In your case, the symptoms you describe—pain, itching, and the presence of a rash around the anal area—are indeed consistent with shingles. However, the misdiagnosis can occur, especially if the rash is not yet vesicular (blistering) or if the presentation is atypical. The initial treatment with pain relievers and anti-inflammatory medications may provide temporary relief, but it does not address the underlying viral infection.

When shingles is suspected, antiviral medications such as acyclovir, valacyclovir, or famciclovir should be initiated as soon as possible, ideally within 72 hours of the onset of the rash. These medications can significantly reduce the severity and duration of the symptoms, as well as the risk of complications such as postherpetic neuralgia, which is persistent pain in the area where the shingles rash occurred.

The fact that you were prescribed antibiotics suggests that the healthcare provider may have suspected a secondary bacterial infection, especially if the rash was oozing or if there were signs of infection. However, antibiotics are ineffective against viral infections like shingles. The improvement you experienced while on antibiotics could be due to the treatment of a secondary infection rather than a resolution of the shingles itself.

If the symptoms persist or worsen after stopping antibiotics, it is essential to revisit the possibility of shingles. A definitive diagnosis can sometimes be made through a physical examination, but laboratory tests can also be helpful. Polymerase chain reaction (PCR) testing of the fluid from the blisters or a direct fluorescent antibody test can confirm the presence of the varicella-zoster virus. Blood tests can also be done to check for antibodies to the virus, but these are less commonly used for acute diagnosis.

Given the complexity of your symptoms and the challenges you've faced with treatment, it may be beneficial to seek care at a larger medical facility where specialists in infectious diseases or dermatology can provide a more comprehensive evaluation. They may also consider other potential causes for your symptoms, such as other viral infections, skin conditions, or even allergic reactions.

In summary, if you suspect shingles, it is crucial to seek prompt treatment with antiviral medications rather than relying solely on pain management or antibiotics. Early intervention can lead to better outcomes and help prevent complications. If your symptoms do not improve or if you have concerns about the diagnosis, do not hesitate to seek a second opinion or further evaluation from a specialist.

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