Uterine Fibroids: Growth Rate, Risks, and Surgical Options - Obstetrics and Gynecology

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Uterine fibroids


Hello, doctor.
In April of this year, an abdominal ultrasound at the gynecology clinic revealed that one of my uterine fibroids has grown to 8.8 cm (it can be felt with light pressure on the lower abdomen).
Two years ago, it was only 5 or 6 cm in size.
I also have iron deficiency anemia (currently being treated with medication after evaluation by the hematology-oncology department) and a long-standing issue with intermittent constipation.
Based on the growth rate of this fibroid, what is the likelihood of malignancy? If surgery is necessary, what types of procedures might be considered? If I wait another six months before having surgery, what potential risks should I be aware of during this time? Thank you.

Lin, 20~29 year old female. Ask Date: 2021/08/07

Dr. Chen Zhiyu reply Obstetrics and Gynecology


Regarding your concerns, here is a summary of the response: It is evident that this tumor is growing rapidly and consuming blood.
The determination of whether it is benign or malignant can only be confirmed through surgical biopsy of the tumor; other methods are merely speculative.
Although minimally invasive surgery has become relatively common, whether it can be applied to your current condition requires a professional physician's assessment after examination.
Given your age and the presence of a tumor that you are already aware is problematic, delaying treatment for another six months will likely increase the uncertainties involved, and the changes at that time could be difficult to predict.
From a health perspective, it is truly important to consider taking proactive measures.
Thank you for your inquiry, and I wish you health and happiness.

Reply Date: 2021/08/07

More Info


Uterine fibroids, also known as leiomyomas, are benign tumors that develop in the uterus. They are quite common, especially among women of reproductive age. Your recent ultrasound findings indicate that one of your fibroids has grown significantly from 5-6 cm to 8.8 cm over the past two years. This rapid growth, along with your symptoms of iron deficiency anemia and intermittent constipation, raises important questions regarding the nature of the fibroid, potential malignancy, and treatment options.


Growth Rate and Malignancy Risk
The growth rate of uterine fibroids can vary widely. Generally, fibroids that grow rapidly, particularly those that double in size within a year, may warrant closer examination. While the vast majority of fibroids are benign, there is a small risk (approximately 0.5% to 1%) that a fibroid can undergo malignant transformation into a type of cancer called leiomyosarcoma. However, this is rare, and the likelihood increases with factors such as age, rapid growth, and certain imaging characteristics. Given that your fibroid has grown significantly, it is essential to monitor it closely, and a surgical intervention may be necessary for definitive diagnosis and treatment.


Surgical Options
If surgery is indicated, there are several options available depending on your specific situation, including:
1. Myomectomy: This is the surgical removal of the fibroid while preserving the uterus. It is often recommended for women who wish to retain their fertility. However, it may not be suitable if the fibroid is large or if there are multiple fibroids.

2. Hysterectomy: This procedure involves the complete removal of the uterus and is typically recommended if the fibroids are large, symptomatic, or if there is a concern about malignancy. Given your fibroid's size and your symptoms, this may be a consideration.

3. Uterine Artery Embolization (UAE): This is a minimally invasive procedure that blocks the blood supply to the fibroids, causing them to shrink. However, it is not suitable for all patients, especially those who may want to conceive in the future.

4. Laparoscopic or Robotic Surgery: These are minimally invasive techniques that can be used for myomectomy or hysterectomy, leading to shorter recovery times and less postoperative pain.


Risks of Delaying Surgery
If you choose to delay surgery for six months, there are several risks to consider:
- Increased Symptoms: As the fibroid continues to grow, you may experience worsening symptoms such as pelvic pain, pressure, heavy menstrual bleeding, or urinary issues.

- Anemia: Your existing iron deficiency anemia could worsen if heavy menstrual bleeding continues, leading to fatigue and other complications.

- Potential for Malignancy: While the risk is low, the possibility of malignant transformation increases with time and growth.

- Impact on Quality of Life: Persistent symptoms can significantly affect your daily activities and overall well-being.


Conclusion
In summary, while uterine fibroids are typically benign, your case requires careful monitoring due to the rapid growth and associated symptoms. It is crucial to discuss your options with your healthcare provider, who can guide you based on your specific circumstances, including the size of the fibroid, your symptoms, and your reproductive plans. Regular follow-ups and imaging may also be necessary to monitor the fibroid's growth and any changes in your condition. Prioritizing your health and addressing these concerns proactively is essential for your well-being.

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