Medication Effects on Liver Function in Prostatitis Treatment - Urology

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Medication issues


Hello Doctor, I have been undergoing treatment for prostatitis for a month and a half.
The medications prescribed by my doctor are as follows: Lyrica pain relief tablets, Urofit enteric-coated tablets 200 mg (Flavoxate), Doxycycline enteric-coated capsules 100 mg (Doxycycline), and Mesna 5 mg (Becaplermin), as well as Sustained-release sublingual tablets 0.2 mg.
I had a blood test yesterday (not at a urology clinic), and today I reviewed the report, which shows my liver function tests: GPT 52 (normal is below 40) and GOT 30 (normal is below 40).
I have heard that antibiotics may cause mild liver function abnormalities.
I would like to ask the doctor if my elevated GPT could be due to the medications used for prostatitis.
If so, will my liver function return to normal after I recover and discontinue the medications? Thank you, Doctor.

Niming, 20~29 year old female. Ask Date: 2021/08/20

Dr. Du Shixi reply Urology


Hello: The abnormal liver function test results in this context should prompt further investigation.
It is not appropriate to attribute elevated liver function solely to medication use.
While it is possible for medications to cause liver function abnormalities, the safety profiles of current medications are generally good, and the likelihood of such occurrences is low.
Wishing you good health.

Reply Date: 2021/08/20

More Info


When considering the effects of medications on liver function, especially in the context of prostatitis treatment, it is essential to understand the potential impact of the specific drugs being used. In your case, you have been prescribed a combination of medications, including pain relievers, antibiotics, and other agents, which may have varying effects on liver enzymes.

Firstly, it is important to note that elevated liver enzymes, such as GPT (ALT) and GOT (AST), can indicate liver stress or damage. Your reported GPT level of 52 is above the normal range (which is typically below 40), while your GOT level is within the normal limits. While it is true that certain medications, particularly antibiotics, can lead to mild elevations in liver enzymes, it is not always the case. The medications you mentioned include:
1. Pain Relievers (e.g., Paracetamol): While generally safe at recommended doses, excessive use can lead to liver toxicity. It is crucial to adhere to the prescribed dosage to avoid potential liver damage.

2. Antibiotics (e.g., Doxycycline): This class of antibiotics is generally considered safe for the liver, but in rare cases, they can cause liver enzyme elevations. The risk is usually low, especially if there are no pre-existing liver conditions.

3. Other Medications (e.g., Betamethasone): Corticosteroids like Betamethasone can have various effects on the body, including potential impacts on liver function, particularly with long-term use. However, short-term use is less likely to cause significant liver issues.

Given your situation, it is plausible that the combination of medications, along with the underlying condition of prostatitis, could contribute to the mild elevation in liver enzymes. However, it is also important to consider other factors that may influence liver function, such as alcohol consumption, diet, and any underlying liver conditions.

Regarding your concern about whether your liver enzyme levels will return to normal after stopping the medications, the answer is generally yes. If the medications are the cause of the elevation, discontinuing them should lead to a gradual normalization of liver function tests. However, this process can take time, and regular monitoring of liver enzymes is advisable to track any changes.

In conclusion, while it is possible that the medications prescribed for your prostatitis treatment may have contributed to the mild elevation in liver enzymes, it is essential to consider the broader context of your health. It is advisable to discuss your concerns with your healthcare provider, who can evaluate your liver function tests in conjunction with your overall health status and make recommendations for further management. Regular follow-up and monitoring will be key to ensuring your liver health remains stable as you continue your treatment for prostatitis.

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