Side Effects of IBS Medications: What to Expect - Gastroenterology and Hepatology

Side effects of medications for irritable bowel syndrome (IBS)?

Hello Doctor: I went to the hospital on September 3rd for abdominal pain, and the doctor diagnosed me with constipation-predominant irritable bowel syndrome.
I was prescribed two medications: 1.
FIatin (Caitlon) 40 mg/tablet and 2.
Magnesium Oxide.
The first medication is to be taken twice a day, and the label mentions side effects such as nausea, vomiting, dizziness, and headaches.
Starting from the 4th, I noticed that about 3 to 4 hours after taking the medication, I experienced mild headaches that lasted for a few hours.
On the morning of the 7th, after taking the medication, I again started to develop a headache after some time, but this time it intensified in the afternoon, and I began to feel mild nausea in the evening.
The symptoms eased during dinner, so I continued taking the medication after my meal.
After a short while, the nausea worsened and took about 2 hours to subside.
I thought it was just a side effect of the medication and that I would feel better after a sleep, so I didn’t take any pain relievers.
However, when I woke up the next morning, the headache persisted.
Is this medication long-acting? Is it normal for the side effects to last this long? The side effects were not as strong in the first three days, but they became intense and prolonged on September 7th.

Weiwei, 20~29 year old female. Ask Date: 2021/09/08

Dr. Lin Minghui reply Gastroenterology and Hepatology

Hello, Flatin contains Otilonium bromide, which is indicated for the relief of abdominal pain associated with irritable bowel syndrome.
It acts as a smooth muscle relaxant in the gastrointestinal tract, with a duration of action of up to 12 hours.
According to the package insert, the following adverse reactions may be associated with the use of Otilonium bromide, with the frequency classified as uncommon: ≥1/1000 to <1/100, including mild fatigue, nausea, dry mouth, vomiting, dizziness, headache, upper abdominal pain, itching, erythema, and vertigo.
It is recommended to discontinue the medication if dizziness is suspected to be a side effect.
If dizziness persists, other causes should be investigated.
Wishing you safety and health.
Sincerely, Dr.
Lin Ming-Hui, Attending Physician, Gastroenterology Department, Taoyuan Hospital, Ministry of Health and Welfare.

Reply Date: 2021/09/08

More Info

When it comes to managing Irritable Bowel Syndrome (IBS), understanding the side effects of medications is crucial for both patients and healthcare providers. IBS is a complex gastrointestinal disorder characterized by symptoms such as abdominal pain, bloating, and altered bowel habits, which can include diarrhea, constipation, or a combination of both. The medications prescribed for IBS, such as the ones you mentioned—FIatin (Caitlon) and Magnesium Oxide—can indeed have side effects that may affect your overall experience with the treatment.

FIatin, which is often used to alleviate intestinal spasms, can cause side effects such as nausea, vomiting, dizziness, and headaches. The onset of these symptoms after taking the medication, as you described, is not uncommon. It’s important to note that while some patients may tolerate the medication well, others may experience adverse effects that can vary in intensity and duration. The fact that you experienced mild headaches and nausea after taking the medication suggests that your body may be reacting to it, which is something that should be monitored closely.

The duration of side effects can vary significantly among individuals. While some may find that side effects dissipate within a few hours, others may experience prolonged symptoms, as you have noted. It is also worth mentioning that the timing of when you take the medication—whether on an empty stomach or after meals—can influence how your body reacts. Taking medications with food can sometimes mitigate gastrointestinal side effects, but this is not a universal rule.

Regarding the question of whether FIatin is a long-acting medication, it typically depends on the specific formulation and the individual's metabolism. Some medications are designed to have a prolonged effect, while others are intended for short-term relief. If you are experiencing persistent side effects that last longer than expected, it is advisable to consult your healthcare provider. They may consider adjusting your dosage, switching medications, or providing additional treatments to alleviate the side effects.

In the case of Magnesium Oxide, it is often used as a laxative or to manage constipation. While it can be beneficial for some, it may also lead to gastrointestinal discomfort, including cramping or diarrhea, especially if taken in excess. If you are experiencing significant discomfort, it may be worth discussing with your doctor whether this medication is appropriate for your situation.

In summary, while medications for IBS can be effective in managing symptoms, they can also lead to side effects that may impact your quality of life. It is essential to maintain open communication with your healthcare provider about any adverse reactions you experience. They can help you navigate these challenges, potentially adjusting your treatment plan to find a balance that alleviates your IBS symptoms while minimizing side effects. Remember, managing IBS often requires a comprehensive approach that includes dietary changes, lifestyle modifications, and sometimes psychological support, in addition to medication.

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