Is High Vitamin B12 a Concern? Risks and Symptoms - Family Medicine

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Excessive Vitamin B12 levels


Hello Doctor, last year during my health check-up, my vitamin B12 level was elevated at 1033 [197][771].
Should I follow up with another test this year? I usually take B-complex vitamins; could this be affecting my levels? Additionally, I found online that high levels of vitamin B12 (cobalamin) in the blood may be associated with cancer.
I also experience a persistent burning sensation in my mouth and on my tongue, and my oral mucosa often gets ulcerated, but my ENT examination was normal.
Thank you for your response.

kk, 40~49 year old female. Ask Date: 2021/10/05

Dr. Liao Yaopan reply Family Medicine


Hello, there are indeed some articles online regarding vitamin B12 overdose, but there are not many research reports on its effects on health or physiology.
The causal relationship with cancer has not been confirmed.
However, normal doses of B vitamins should not cause harmful overdoses, so it is important to be cautious and not exceed the recommended dosage.
If you continue to experience discomfort, you should seek medical evaluation.
Online consultations are not equivalent to in-person medical visits and cannot provide diagnoses or treatment recommendations.
Changhua Hospital cares about you.

Reply Date: 2021/10/05

More Info


High levels of Vitamin B12 in the blood can be a concern, but the implications depend on various factors, including the underlying cause of the elevation and the presence of any symptoms. Vitamin B12, also known as cobalamin, is a water-soluble vitamin that plays a crucial role in nerve function, red blood cell formation, and DNA synthesis. It is primarily obtained from animal products, and deficiencies can lead to serious health issues, including anemia and neurological problems.

In your case, a Vitamin B12 level of 1033 pg/ml is above the normal range (typically 200-900 pg/ml). While high levels of B12 are often not harmful due to its water-soluble nature—meaning excess amounts are usually excreted through urine—persistent elevations can sometimes indicate underlying health issues. These may include liver disease, certain types of leukemia, or other hematological disorders. Therefore, it is advisable to follow up with your healthcare provider for further evaluation, especially if you have symptoms or if the levels remain elevated in subsequent tests.

Regarding your concern about a potential link between high B12 levels and cancer, research on this topic is limited and somewhat inconclusive. Some studies have suggested that elevated B12 levels could be associated with certain cancers, but this relationship is not well understood and does not imply causation. It is essential to consider other factors, such as overall health, lifestyle, and any additional symptoms you may be experiencing.

You mentioned experiencing a burning sensation in your mouth and frequent sores on your cheeks. These symptoms can be distressing and may not be directly related to your B12 levels. Oral discomfort can arise from various causes, including nutritional deficiencies (such as iron or folate), allergic reactions, infections, or even stress. Since your ENT examination was normal, it may be beneficial to consult with a dentist or an oral health specialist to explore potential causes and treatments for your oral symptoms.

As for your routine intake of B vitamins, including B12, it is crucial to ensure that you are not exceeding recommended dosages, especially if you are taking supplements. While B12 supplementation is generally safe, excessive intake can lead to complications, particularly if there are underlying health conditions. If you are taking B12 injections or high-dose supplements, it would be wise to discuss this with your healthcare provider to determine the appropriate dosage for your needs.

In summary, while high Vitamin B12 levels can be concerning, they are not always indicative of a serious problem. It is essential to monitor your levels and consult with your healthcare provider for further evaluation and to address any symptoms you may be experiencing. Regular follow-up tests can help determine if the elevation is persistent and if any additional investigations are warranted. Maintaining a balanced diet and being mindful of your supplement intake can also contribute to your overall health and well-being.

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