Increased Sweating After Starting Plaquenil: Is It Related?

After taking Belviq, I started sweating more than before?

Hello Doctor: Two months ago, I went to the hospital for an examination and found that I have genes similar to lupus erythematosus, but I am still in the pre-symptomatic stage.
Therefore, the doctor prescribed me 200 mg of Plaquenil (hydroxychloroquine) to take once daily.
However, since I started taking the medication, I have been sweating excessively; even with just a little humidity, I start to sweat before I even feel hot.
Could this be related to the medication? Thank you.

cc, 20~29 year old female. Ask Date: 2021/10/12

Dr. Gao Jiankai reply Internal Medicine

Hello, thank you for your inquiry.
Based on my clinical experience and information regarding the side effects of this medication, it appears that excessive sweating is not a common side effect.
The Allergy, Immunology, and Rheumatology Department at Changhua Hospital, Ministry of Health and Welfare, is here to assist you.

Reply Date: 2021/10/12

More Info

Increased sweating, or hyperhidrosis, can indeed be a side effect of various medications, including Plaquenil (hydroxychloroquine). This medication is commonly used to treat autoimmune conditions such as lupus and rheumatoid arthritis. While it is generally well-tolerated, some patients report side effects, including increased sweating.

The mechanism behind this side effect is not entirely understood, but it may be related to the drug's effects on the central nervous system or its influence on the body's thermoregulation processes. Hydroxychloroquine can affect the autonomic nervous system, which controls involuntary bodily functions, including sweating. When the body perceives a slight increase in temperature or humidity, the autonomic nervous system may trigger sweat production as a cooling mechanism. If you are experiencing excessive sweating after starting Plaquenil, it is plausible that the medication is contributing to this symptom.

It is important to note that individual responses to medications can vary widely. Some people may experience side effects that others do not, and the severity of these effects can also differ. If you find that your sweating is excessive or bothersome, it is advisable to discuss this with your healthcare provider. They may consider adjusting your dosage or exploring alternative medications that may not have the same side effects.

In addition to medication-related causes, other factors can contribute to increased sweating. These include anxiety, stress, hormonal changes, and environmental factors such as heat and humidity. It is essential to assess your overall situation, including lifestyle factors, to determine if there are additional contributors to your sweating.

If the sweating is accompanied by other symptoms, such as fever, chills, or significant changes in your health, it is crucial to seek medical attention. These could indicate an underlying issue that requires further investigation.

In summary, increased sweating after starting Plaquenil could be related to the medication, but it is essential to consider other potential factors as well. Open communication with your healthcare provider is key to managing any side effects effectively. They can help you weigh the benefits of the medication against its side effects and make informed decisions about your treatment plan.

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