Norethisterone and Premarin: Impact on Conception and Fertility - Obstetrics and Gynecology

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Medication Consultation (Preconception)


1.
I would like to ask if Norethisterone/Premarin 0.625 has contraceptive effects.
My menstrual period started on October 3 and ended on October 7.
After that, I experienced abnormal bleeding, which I consulted a doctor about.
The doctor prescribed these two medications (Norethisterone/Premarin) to stop the bleeding for one week.
When I returned for a follow-up on October 21, I was given another week's supply of the same medications, with the advice that my next menstrual cycle would help regulate my periods.
During the consultation, I asked if this would affect my fertility, and the doctor said it would not.
However, I found some information suggesting that there may be contraceptive components.
Will taking Norethisterone/Premarin affect my chances of getting pregnant while trying to conceive?
2.
I have been trying to conceive for a while without success.
Should I undergo infertility testing?

Xiao An, 20~29 year old female. Ask Date: 2021/10/21

Dr. Lin Manying reply Obstetrics and Gynecology


Hello, based on your inquiry, here are the responses: 1.
These medications prescribed by your doctor during abnormal bleeding are not regular contraceptives; they are for menstrual regulation.
2.
If you are not using contraception and have not conceived after a year, you may consider undergoing infertility testing.
The Hualien Hospital of the Ministry of Health and Welfare cares about your health.

Reply Date: 2021/10/21

More Info


Norethisterone and Premarin are medications commonly used in gynecological practice, particularly for managing menstrual irregularities and hormonal imbalances. Understanding their effects on fertility and conception is crucial for individuals who are planning to conceive.

1. Contraceptive Effects of Norethisterone and Premarin: Norethisterone is a synthetic progestin, while Premarin is a conjugated estrogen. These medications are not primarily designed as contraceptives, but they can have effects on the menstrual cycle that may influence fertility. When prescribed for abnormal bleeding or to regulate menstrual cycles, their primary purpose is to restore hormonal balance rather than to prevent pregnancy.
In your case, the doctor prescribed Norethisterone and Premarin to manage abnormal bleeding and to help regulate your menstrual cycle. While these medications can alter the menstrual cycle, they do not provide reliable contraceptive protection. Therefore, if you are trying to conceive, it is essential to discuss with your healthcare provider when it is appropriate to stop these medications to allow for natural ovulation and conception.

Regarding the concern about their impact on fertility, Norethisterone and Premarin are typically not associated with long-term fertility issues. However, they can temporarily affect ovulation and the menstrual cycle while you are taking them. It is advisable to follow your doctor's guidance on when to discontinue these medications to optimize your chances of conception.

2. Fertility Evaluation: If you have been trying to conceive for an extended period without success, it may be appropriate to consider fertility evaluations. Generally, if a couple has been trying to conceive for over a year without success (or six months if the woman is over 35), it is recommended to seek a fertility assessment. This evaluation can include tests for ovulation, sperm analysis, and assessments of reproductive health for both partners.

It is essential to communicate openly with your healthcare provider about your concerns regarding fertility and the use of medications like Norethisterone and Premarin. They can provide personalized advice based on your medical history and current health status.

In summary, while Norethisterone and Premarin can influence your menstrual cycle and may temporarily affect ovulation, they are not intended as contraceptives. If you are planning to conceive, it is crucial to discuss the timing of discontinuing these medications with your healthcare provider. Additionally, if you have been trying to conceive for a significant period without success, pursuing fertility evaluations is a reasonable next step to identify any underlying issues that may be affecting your ability to conceive. Always consult with your healthcare provider for tailored advice and recommendations based on your specific situation.

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