Recurrence and HPV Persistence in Urology - Urology

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Possibility of recurrence or persistence?


Hello Doctor, I underwent electrosurgery for genital warts in early August last year and started using LedaMed.
Three months later (in December), during my follow-up appointment, the doctor said there was no recurrence (no HPV testing was done, just an examination of the originally affected vulva and an additional examination of the uterus).
I have started receiving the HPV vaccine and have completed the quadrivalent vaccination this year.
To date, there has been no recurrence (I have had Pap smears and pelvic exams during each follow-up visit for the vaccinations).
I would like to ask the doctor: (1) Is there a high probability that the virus still exists in my body? (2) If I plan to conceive in the future, how long after the entire treatment is it appropriate to try for pregnancy? Thank you.

Mimi, 20~29 year old female. Ask Date: 2021/10/24

Dr. Cai Zhuorong reply Urology


According to research, the human papillomavirus (HPV) may be cleared by the immune system within two years after treatment; however, there are cases where it remains latent in the body for a longer period.
If a gynecological examination confirms that there are no lesions, fertility should not be affected.

Reply Date: 2021/10/24

More Info


Understanding the complexities of HPV (Human Papillomavirus) infections, their potential for recurrence, and their implications for reproductive health is crucial for anyone who has experienced related health issues. Your questions touch on important aspects of HPV management and the considerations for future fertility.

1. Likelihood of Persistent HPV Infection: After treatment for HPV-related conditions, such as genital warts or dysplasia, it is possible for the virus to remain in the body. The immune system plays a significant role in controlling HPV infections. While many individuals can clear the virus naturally over time, some may experience persistent infections. Factors influencing persistence include the specific HPV strain, the individual's immune response, and any underlying health conditions. In your case, since you have undergone treatment and received the HPV vaccine, the likelihood of the virus still being present may vary. The vaccine is designed to prevent new infections from certain high-risk HPV types but does not eliminate existing infections. Therefore, if you had a persistent infection before vaccination, it may still be present.

2. Timing for Future Pregnancy: When considering pregnancy after HPV treatment, it is essential to consult with your healthcare provider. Generally, it is advisable to wait until you have completed your treatment and have been monitored for a period to ensure that there are no signs of recurrence or complications. The exact duration can vary based on individual circumstances, including the type of treatment received and the results of follow-up examinations. Many healthcare providers recommend waiting at least six months to a year after treatment before trying to conceive, allowing time for your body to heal and for any potential HPV-related issues to be resolved.

In addition to these points, it is important to maintain regular follow-up appointments with your healthcare provider. This includes routine Pap smears and HPV testing as recommended, as these screenings are vital for monitoring any changes in cervical health and ensuring early detection of any potential issues.

Moreover, if you are planning to become pregnant, discussing your HPV status with your obstetrician or gynecologist is crucial. They can provide personalized advice based on your medical history and current health status. They may also recommend additional screenings or precautions during pregnancy to ensure both your health and that of your future child.

Lastly, while HPV is primarily transmitted through sexual contact, it is essential to understand that the presence of HPV does not necessarily affect fertility. However, certain HPV-related conditions, such as cervical dysplasia or cancer, can have implications for reproductive health. Therefore, addressing any HPV-related concerns proactively is vital for your overall well-being and future family planning.

In summary, while the possibility of persistent HPV infection exists, the vaccine can help prevent new infections. When planning for pregnancy, it is best to consult with your healthcare provider to determine the appropriate timing and ensure that you are in optimal health. Regular monitoring and open communication with your healthcare team will be key in managing your HPV status and reproductive health.

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