Male Hormonal Imbalance: Symptoms Similar to PMS - Obstetrics and Gynecology

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Symptoms similar to premenstrual syndrome (PMS)


I am a male with endocrine disorders, and my estrogen levels are usually as high as 210, while my androgen levels are below 20.
During episodes of symptoms, my estrogen levels can exceed 600, at which point I experience severe discomfort, including nausea, fatigue, muscle aches, insomnia, diarrhea, abdominal pain, dizziness, and breast tenderness (I have gynecomastia with a B cup).
I also find myself easily brought to tears, especially when reading certain tragic novels or watching animated films, which is more intense than usual.
Is this a personal issue? My doctor mentioned that this is similar to premenstrual syndrome (PMS) in women, due to the significant fluctuations in my estrogen levels over a short period.
Is this true? Can extreme fluctuations in estrogen levels in men trigger reactions similar to PMS in women? Is my doctor's diagnosis accurate?

Liao Xiansheng, 20~29 year old female. Ask Date: 2021/11/18

Dr. Lin Xinwang reply Obstetrics and Gynecology


Hello Mr.
Liao: An imbalance in estrogen levels, whether too high or too low, or experiencing significant fluctuations, can lead to physical discomfort.
This type of endocrine disruption is similar to the bodily discomfort caused by hormonal changes during premenstrual syndrome (PMS).
If you continue to experience these issues, please seek ongoing outpatient treatment.

Reply Date: 2021/11/18

More Info


Understanding male hormonal imbalance, particularly the effects of elevated estrogen levels, is crucial for recognizing symptoms that can mimic those of premenstrual syndrome (PMS) in women. Your situation, where estrogen levels are significantly higher than testosterone, can lead to a range of physical and emotional symptoms that are indeed comparable to PMS.


Symptoms of Hormonal Imbalance
In men, hormonal imbalances can manifest in various ways, particularly when estrogen levels rise. The symptoms you described—nausea, fatigue, muscle aches, insomnia, gastrointestinal issues, dizziness, breast tenderness, and emotional sensitivity—are all indicative of such an imbalance. Elevated estrogen can lead to gynecomastia (the development of breast tissue), which you mentioned experiencing. This condition can be distressing and is often linked to hormonal fluctuations.

The emotional symptoms, such as increased tearfulness and sensitivity to sad narratives, can also be attributed to hormonal changes. Estrogen is known to influence mood and emotional regulation, and significant fluctuations can lead to mood swings similar to those experienced during PMS in women. Your physician's comparison to PMS is not unfounded; while PMS is typically associated with the menstrual cycle in women, the underlying hormonal dynamics can produce similar effects in men when estrogen levels are disproportionately high.


The Role of Hormones
In a healthy male endocrine system, testosterone is the dominant hormone, while estrogen is present in much lower levels. However, factors such as obesity, certain medications, and health conditions can lead to increased conversion of testosterone to estrogen, resulting in elevated estrogen levels. This imbalance can disrupt the normal physiological processes and lead to the symptoms you are experiencing.


Diagnosis and Treatment
Your physician's diagnosis seems reasonable given the symptoms and hormonal levels you've described. It is essential to conduct a thorough evaluation, including blood tests to monitor hormone levels over time, to understand the underlying causes of your hormonal imbalance. Treatment options may include lifestyle changes, such as diet and exercise, medications to manage hormone levels, or addressing any underlying health conditions contributing to the imbalance.


Emotional and Psychological Impact
The emotional symptoms you are experiencing, such as increased sensitivity and tearfulness, can be particularly challenging. Hormonal imbalances can affect neurotransmitter systems in the brain, leading to mood disturbances. It is important to address these symptoms holistically, considering both hormonal treatment and psychological support if needed. Counseling or therapy can provide coping strategies for managing emotional responses and improving overall mental health.


Conclusion
In summary, your experience of hormonal imbalance and its symptoms is valid and can indeed resemble those of PMS in women. The fluctuations in estrogen levels can lead to a variety of physical and emotional symptoms that warrant attention. It is crucial to work closely with your healthcare provider to monitor your hormone levels and explore appropriate treatment options. Understanding the interplay between hormones and emotional health can empower you to take proactive steps towards achieving balance and improving your quality of life.

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