Can You Get the AZ Vaccine While Taking Diane? - Obstetrics and Gynecology

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Can I receive the AZ vaccine while taking Diane?


Hello doctor, I am currently taking Diane-35 for polycystic ovary syndrome and have nearly finished my second pack, which I plan to complete by November 24.
However, I am scheduled to receive my second dose of the AZ vaccine on November 22.
Is there any conflict between the two? Should I stop taking the medication starting from November 20 before getting vaccinated?

Ms. Li, 20~29 year old female. Ask Date: 2021/11/19

Dr. Wu Xianghui reply Obstetrics and Gynecology


It is recommended to refrain from use for 2 weeks after administration.

Reply Date: 2021/11/19

More Info


When considering vaccination with the AstraZeneca (AZ) vaccine while taking Diane (a combination oral contraceptive), it is important to understand the interactions and safety profiles of both the medication and the vaccine. Diane is commonly prescribed for conditions such as polycystic ovary syndrome (PCOS) and is a form of hormonal birth control that contains estrogen and progestin.

Based on current medical guidelines and research, there is no direct contraindication to receiving the AZ vaccine while on Diane. The AZ vaccine works by stimulating the immune system to recognize and fight the SARS-CoV-2 virus, which causes COVID-19, and it does not interact with the hormonal components of Diane. Therefore, you should not need to stop taking Diane prior to your vaccination.

However, it is advisable to consult with your healthcare provider before making any decisions. They can provide personalized advice based on your medical history and current health status. If you have any concerns about potential side effects or interactions, discussing these with your doctor will help ensure that you are making an informed decision.

In general, the following points should be considered when planning to receive the AZ vaccine while on Diane:
1. Timing of Vaccination: It is recommended to maintain your regular medication schedule and receive the vaccine as planned. There is no need to alter your medication regimen unless specifically advised by your healthcare provider.

2. Monitoring for Side Effects: After receiving the vaccine, monitor for any side effects, which may include mild symptoms such as soreness at the injection site, fatigue, or mild fever. These are common reactions to vaccines and are generally not related to the use of Diane.

3. Consultation with Healthcare Provider: If you experience any unusual symptoms or have concerns about your health, reach out to your healthcare provider for guidance. They can help determine if any further evaluation is needed.

4. General Health Considerations: Ensure that you are in good health on the day of vaccination. If you are feeling unwell or have any acute illness, it may be advisable to postpone the vaccination until you are feeling better.

5. Post-Vaccination Care: After receiving the vaccine, it is recommended to stay at the vaccination site for at least 15 minutes for observation, especially if you have a history of allergic reactions. This is a precautionary measure to ensure that any immediate adverse reactions can be managed promptly.

In summary, you can safely receive the AZ vaccine while taking Diane without needing to stop the medication beforehand. However, always prioritize communication with your healthcare provider to address any specific concerns or health conditions you may have. They will provide the best guidance tailored to your individual health needs.

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