Fluorescein Angiography: Key Contrast Agent Components Explained

Q: Fluorescein Angiography: Key Contrast Agent Components Explained

Hello PP： The agent used in ophthalmology is a fluorescein dye, with the active ingredient being Fluorescein sodium. <br>It is different from the contrast agents used for cerebral vascular imaging, and each hospital may use different brands. <br>It is best to consult the performi

The name of the "contrast agent" used in fluorescein angiography is fluorescein sodium?

Hello, doctor.
The following information is sourced from the internet:
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When there is a dysfunction in the microcirculation of the eye or a decrease in blood perfusion, nutrients and oxygen cannot meet the metabolic needs of the tissues, and waste products in the tissues and organs cannot be expelled in a timely manner.
This leads to impaired function or even failure of the ocular tissues, which becomes a significant cause of many eye diseases.
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I would like to ask the doctor:
(1) Can fluorescein angiography detect whether the ocular blood circulation is unobstructed?
(2) What is the name of the "contrast agent (components)" used in fluorescein angiography? (I have undergone organ transplantation, and previously when I needed to have a "cerebral angiography," my transplant physician prescribed medication to protect the transplanted organ due to the need for contrast agents.
Therefore, I would like to know the name of the contrast agent components in advance so that my transplant physician can determine what oral medication to prescribe for the protection of the transplanted organ.
Thank you.)

PP, 40~49 year old female. Ask Date: 2021/12/03

Dr. Gao Pilin reply Ophthalmology

Hello PP: The agent used in ophthalmology is a fluorescein dye, with the active ingredient being Fluorescein sodium.
It is different from the contrast agents used for cerebral vascular imaging, and each hospital may use different brands.
It is best to consult the performing physician for clarification.

Reply Date: 2021/12/03

More Info

Fluorescein angiography (FA) is a diagnostic procedure used primarily in ophthalmology to assess the blood flow in the retina and choroid, which are critical components of the eye's vascular system. This technique involves the injection of a fluorescent dye, fluorescein, into the bloodstream, which then travels to the blood vessels in the eye. As the dye circulates, a specialized camera captures images of the retina, allowing for the evaluation of blood flow and the identification of any abnormalities.

1. Assessment of Retinal Blood Flow: Fluorescein angiography is indeed effective in evaluating the circulation of blood in the retinal vessels. It can help determine whether the blood vessels are patent (open) or occluded (blocked). The images produced during FA can reveal various conditions such as diabetic retinopathy, retinal vein occlusion, and age-related macular degeneration. By observing the patterns of dye leakage or non-perfusion, clinicians can assess the health of the retinal vasculature and make informed decisions regarding treatment options.

2. Components of the Contrast Agent: The primary contrast agent used in fluorescein angiography is fluorescein sodium. This compound is a water-soluble dye that fluoresces when exposed to blue light, making it visible in the images captured during the procedure. Fluorescein sodium is typically administered intravenously, and its rapid circulation through the retinal vessels allows for real-time imaging of the blood flow.

Given your history of organ transplantation, it is prudent to discuss any potential risks associated with fluorescein angiography with your healthcare provider. While fluorescein is generally considered safe, there are some considerations for patients with a history of kidney issues or those who have undergone transplantation. The dye is excreted through the kidneys, and in rare cases, it can cause allergic reactions or other adverse effects.
If you have concerns about the safety of fluorescein angiography in the context of your organ transplant, it is essential to communicate this with your transplant physician. They may recommend pre-treatment with medications such as corticosteroids or antihistamines to mitigate any potential allergic reactions. Additionally, they can provide guidance on monitoring kidney function before and after the procedure to ensure that your transplant remains healthy.

In summary, fluorescein angiography is a valuable tool for assessing retinal blood flow and diagnosing various ocular conditions. The primary contrast agent used is fluorescein sodium, which allows for detailed imaging of the retinal vasculature. Given your medical history, it is crucial to work closely with your healthcare team to ensure that any necessary precautions are taken to protect your transplanted organ during the procedure.

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