Abnormal Bleeding After Taking Medroxyprogesterone Acetate - Obstetrics and Gynecology

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Bleeding after taking "Fu An" tablets?


Due to an event at the end of December, I was concerned about my menstrual cycle, so I visited a gynecologist for menstrual regulation.
The first gynecologist prescribed me a 21-day course of premedication: Winstrol WINS1OP28 (DUOLUIONL) and Johnson's Novamin (Prochlorperazine) in orange and white pills.
The doctor instructed me to start taking them on the fifth day of my period.
I took them from November 27 to November 30 (once a day).
After that, I went to a second gynecologist, who advised me to switch to Medroxyprogesterone acetate Fuan 5mg (three times a day).
I asked the doctor if the previous medication would have any effect, and the doctor said it wouldn’t affect me since I had just started taking it.
The doctor also mentioned to start taking it on December 4 (the day of ovulation) and indicated that my period would likely start around December 18.
However, on December 4, after taking the second dose at 4:00 PM, I noticed bleeding when I went to the restroom, and it has continued until today, December 6, with increasing flow and blood clots.
I am changing sanitary pads about once a day, and I am also experiencing menstrual cramps at night.
I am unsure if this is an early onset of my period or if it is a normal reaction to the medication, as I feel symptoms similar to menstruation.
I am uncertain whether I should stop taking the medication since I haven't finished the course.
If I stop now, will my period come again at the end of December? Additionally, how long should I wait before taking Medroxyprogesterone acetate Fuan 5mg again?

Ming, 20~29 year old female. Ask Date: 2021/12/06

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it seems you may be experiencing irregular menstruation.
It is advisable to consult a gynecologist for menstrual regulation.
Wishing you good health.

Reply Date: 2021/12/06

More Info


When it comes to understanding abnormal bleeding after taking Medroxyprogesterone Acetate, it is essential to consider several factors, including the medication's mechanism of action, the timing of administration, and individual physiological responses. Medroxyprogesterone Acetate is a synthetic form of the hormone progesterone, commonly used to regulate menstrual cycles, treat endometriosis, and manage abnormal uterine bleeding.

In your case, you began taking Medroxyprogesterone Acetate after a previous regimen of a different medication. The timing of your medication and the transition between different hormonal treatments can significantly influence your menstrual cycle. It is not uncommon for women to experience irregular bleeding or spotting when starting a new hormonal medication, especially if they have recently switched from another regimen.

The bleeding you are experiencing, which started shortly after taking Medroxyprogesterone Acetate, could be attributed to several factors:
1. Hormonal Fluctuations: When you start taking a new hormonal medication, your body may take time to adjust to the changes in hormone levels. This adjustment period can lead to breakthrough bleeding or spotting, which may feel similar to a menstrual period.

2. Timing of Administration: The timing of when you took the medication in relation to your menstrual cycle is crucial. If you started taking Medroxyprogesterone during your ovulation phase, it could lead to unexpected bleeding as your body responds to the new hormone levels.

3. Dosage and Frequency: You mentioned taking Medroxyprogesterone Acetate three times a day. It is important to adhere to the prescribed dosage and timing to maintain stable hormone levels. If there are inconsistencies in when you take the medication, it could lead to fluctuations in hormone levels, resulting in abnormal bleeding.

4. Underlying Conditions: If you have any underlying conditions, such as uterine fibroids or polyps, these could also contribute to abnormal bleeding patterns. Medroxyprogesterone is sometimes used to manage these conditions, but it may not eliminate bleeding entirely.

Regarding your concerns about whether to continue or stop the medication, it is crucial to consult with your healthcare provider. Stopping the medication abruptly could lead to further irregularities in your menstrual cycle. Your doctor can provide guidance on whether to continue the medication based on your current symptoms and bleeding patterns.

As for the timing of your next dose, it is generally recommended to take Medroxyprogesterone Acetate at consistent intervals to maintain stable hormone levels. If you are unsure about the timing or have missed a dose, consult your healthcare provider for specific instructions.

In summary, while experiencing abnormal bleeding after starting Medroxyprogesterone Acetate can be concerning, it is often a common side effect as your body adjusts to the new hormone levels. It is essential to maintain open communication with your healthcare provider to monitor your symptoms and make any necessary adjustments to your treatment plan. Regular follow-ups will help ensure that your menstrual cycle stabilizes and that any underlying issues are addressed appropriately.

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