Is Oral Treatment for Toenail Fungus Effective After 6 Weeks? - Dermatology

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After six weeks of oral medication for onychomycosis, there is still no new nail growth observed?


Is oral antifungal medication effective for toenail fungus that has persisted for over a decade? I have been taking Terbinafine for six weeks and have not seen any new nail growth.
There is no sign of even a little new nail, and my toenails grow much faster than normal.
I am very concerned about its effectiveness.
If there is no improvement after three months, can I continue to pay out of pocket for the medication? If it is still ineffective, are there other oral medications I can try? I was previously unaware that I needed to apply topical medication continuously, and I have been inconsistent, which makes me worry about potential resistance to the oral medication.
If all treatments fail, I am considering having those toes amputated.
Is there a surgical option to permanently prevent nail growth? Thank you for your help! This toenail fungus significantly impacts my life; I am constantly worried about infecting my child, I can't even put my feet on the bed while sleeping, and after showering, I have to bleach the floor.
I use bleach to mop the floor every day.
I avoid touching shoes and socks, and I wash my hands countless times with body wash and detergent, leaving my hands dry and cracked.

Xiong, 30~39 year old female. Ask Date: 2021/12/09

Dr. Wu Yuxin reply Dermatology


If there is improvement after three months, it will be recommended to continue with out-of-pocket expenses for the medication.
If there is no improvement at all, other types of medication should be considered.

Reply Date: 2021/12/09

More Info


Toenail fungus, medically known as onychomycosis, can be a persistent and frustrating condition to treat. The effectiveness of oral antifungal medications, such as terbinafine (often referred to by its brand name Lamisil), can vary significantly from person to person. After six weeks of treatment, it is not uncommon for patients to feel concerned if they do not see visible improvements, such as new nail growth.
Firstly, it is important to understand that toenails grow slowly, and it can take several months to see significant changes, especially if the infection has been present for a long time. Typically, toenails grow at a rate of about 1 millimeter per month, which means that even if the medication is effective, it may take time for the new, healthy nail to push out the infected portion. If you have been on terbinafine for six weeks and have not noticed any new nail growth, it does not necessarily mean that the treatment is ineffective.
If after three months of treatment there is still no improvement, it is advisable to consult your healthcare provider. They may recommend continuing the treatment if there are signs that the medication is working, such as a reduction in symptoms or changes in the appearance of the nail. However, if there is no progress, your doctor may consider switching to another oral antifungal medication, such as itraconazole (Sporanox) or fluconazole (Diflucan), which may be more effective for your specific type of fungal infection.

Regarding your concerns about potential antifungal resistance, it is important to follow the prescribed treatment regimen consistently. Interruptions in treatment can lead to suboptimal outcomes and may contribute to resistance. If you have been using topical treatments intermittently, this could also affect the overall effectiveness of your oral medication.
In extreme cases where the infection is unresponsive to multiple treatments, surgical options may be considered. This could involve partial or complete nail removal, which can provide relief from the infection and allow for the growth of a new, healthy nail. However, this is typically seen as a last resort after other treatment options have been exhausted.

Additionally, it is crucial to maintain proper foot hygiene and care during treatment. Keeping your feet dry, wearing breathable footwear, and avoiding shared spaces where fungal infections can spread (like swimming pools or communal showers) can help prevent reinfection or worsening of the condition.
Lastly, your emotional and psychological well-being is also important. Living with a chronic condition like toenail fungus can be distressing, especially with concerns about hygiene and the risk of transmission to family members. It may be beneficial to speak with a healthcare professional about these concerns, as they can provide support and strategies to manage both the physical and emotional aspects of living with this condition.

In summary, while six weeks of oral treatment for toenail fungus may not yield visible results, it is essential to continue monitoring the situation and maintain open communication with your healthcare provider. They can guide you on the best course of action, whether that involves continuing the current treatment, switching medications, or considering surgical options.

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