Can Cord Blood Stem Cells Treat Night Blindness? Expert Insights Needed - Ophthalmology

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Is umbilical cord blood stem cells suitable for treating night blindness?


Hello Doctor, I am currently about 22 weeks pregnant and would like to confirm how umbilical cord blood stem cells can be evaluated for the treatment of night blindness.
My mother, who is 59 years old, has been diagnosed with night blindness and holds a severe disability certificate.
I couldn't find suitable answers online, so I would like to know what steps to take or whom to consult.
My mother is currently seeing a doctor at the hospital (still in the process of being referred to an appropriate specialist) to see if her condition can be stabilized.
Previously, a doctor mentioned that it might be hereditary, and now I have learned that my mother is the most severely affected in our family, while other relatives have mild cases.
Do you have any recommendations on when family members should be screened or how to prevent this condition? Thank you!

Lesley, 30~39 year old female. Ask Date: 2021/12/10

Dr. Gao Pilin reply Ophthalmology


Hello Lesley: "Retinitis Pigmentosa (RP)" is a genetic disorder, and the condition of patients tends to worsen over time.
Currently, treatment options are limited, and there is no way to prevent it.
There are experimental gene therapies available abroad, but such treatments are not yet available in Taiwan.
Please refer to the following links: https://bit.ly/3dGvF60 https://bit.ly/3dEBzEM

Reply Date: 2021/12/10

More Info


Night blindness, or nyctalopia, is a condition that affects a person's ability to see in low-light conditions. It can be caused by various factors, including genetic disorders, vitamin A deficiency, and certain retinal diseases. In your case, it appears that your mother has been diagnosed with a hereditary form of night blindness, which may be linked to genetic mutations affecting the retina.

Currently, the treatment options for night blindness are limited, especially when it comes to genetic forms of the disease. While there has been research into the use of stem cells for various conditions, including retinal diseases, the application of cord blood stem cells specifically for treating night blindness is still largely experimental and not widely established in clinical practice.

Cord blood stem cells have shown promise in regenerative medicine due to their ability to differentiate into various cell types. However, their effectiveness in treating retinal diseases, including night blindness, is not yet well-documented. Most studies focus on conditions like retinal degeneration or age-related macular degeneration, and even then, the results are preliminary. The use of stem cells for retinal repair is still in the research phase, and there are no established protocols for using cord blood stem cells to treat night blindness directly.

If you are considering stem cell therapy for your mother, it is crucial to consult with a specialist in ophthalmology or a retinal specialist who is knowledgeable about the latest advancements in stem cell research and therapies. They can provide insights into whether any clinical trials are available that might be suitable for your mother’s condition.

In terms of genetic testing and family history, it is advisable for family members to undergo genetic counseling and testing if there is a known hereditary condition. This can help identify whether other family members are at risk and provide guidance on monitoring and managing potential symptoms. Genetic counselors can also offer information about the inheritance patterns of the condition and discuss options for family planning.

As for prevention, since night blindness can be associated with vitamin A deficiency, ensuring that your mother has a well-balanced diet rich in vitamin A may help manage her symptoms. Foods such as carrots, sweet potatoes, spinach, and other leafy greens are excellent sources of this vitamin. However, if the night blindness is primarily genetic, dietary changes may not significantly alter the progression of the disease.

In summary, while cord blood stem cells hold potential for various medical applications, their role in treating night blindness is not yet established. It is essential to seek expert advice from healthcare professionals specializing in retinal diseases and genetics to explore the best options for your mother’s condition. Regular check-ups and monitoring of her eye health will also be crucial in managing her night blindness effectively.

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