HPV 9-Valent Vaccine Reactions and Herpes Recurrence - Dermatology

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HPV 9-valent vaccine


Hello, I received the HPV 9-valent vaccine two weeks ago, and that same night I developed mouth sores, followed by an outbreak of cold sores, which I haven't experienced in over a decade.
Could this recurrence be related to the vaccination? Given this reaction, can I continue with the second and third doses? Thank you, doctor.

Xiao Jie, 40~49 year old female. Ask Date: 2021/12/11

Dr. Wu Yuxin reply Dermatology


Currently, there is no evidence to suggest a correlation.

Reply Date: 2021/12/11

More Info


The 9-valent HPV vaccine (Gardasil 9) is designed to protect against nine strains of the human papillomavirus (HPV), which are associated with various cancers and genital warts. While the vaccine is highly effective in preventing HPV-related diseases, some individuals may experience side effects or reactions after vaccination, including the recurrence of herpes simplex virus (HSV) infections, such as cold sores.

In your case, it is important to consider a few key points regarding the relationship between the HPV vaccine and the recurrence of herpes simplex virus:
1. Vaccine Side Effects: Common side effects of the HPV vaccine include pain at the injection site, fever, headache, and fatigue. However, the vaccine is not known to directly cause herpes outbreaks. The immune response triggered by the vaccine may temporarily alter your immune system's balance, potentially leading to the reactivation of dormant viruses like HSV in some individuals, especially if they have a history of herpes infections.

2. Herpes Recurrence: Herpes simplex virus can remain dormant in the body after the initial infection and may reactivate due to various triggers, including stress, illness, or changes in the immune system. If you have not experienced an outbreak in over a decade, it is possible that the stress or immune response associated with receiving the vaccine could have contributed to the recurrence of your cold sores.

3. Continuing the Vaccination Series: It is generally recommended to complete the HPV vaccination series, as the full protection against HPV-related diseases is achieved after receiving all doses. If you experienced a herpes outbreak after the first dose, it does not contraindicate receiving the subsequent doses of the HPV vaccine. However, it is advisable to consult with your healthcare provider before proceeding. They can assess your individual health situation and provide personalized recommendations.

4. Consulting a Healthcare Provider: If you are concerned about the recurrence of herpes or any other side effects following the HPV vaccination, it is essential to discuss these concerns with your healthcare provider. They can help determine whether your symptoms are related to the vaccine and guide you on the best course of action, including whether to continue with the remaining doses.

5. Managing Herpes Outbreaks: If you experience recurrent herpes outbreaks, your healthcare provider may recommend antiviral medications to help manage symptoms and reduce the frequency of outbreaks. It is also beneficial to maintain a healthy lifestyle, manage stress, and avoid known triggers to minimize the risk of recurrence.

In summary, while the HPV 9-valent vaccine is an important tool in preventing HPV-related diseases, it is not directly linked to causing herpes outbreaks. If you have concerns about your health following vaccination, it is best to consult with a healthcare professional who can provide tailored advice and support. Completing the vaccination series is crucial for optimal protection, and your healthcare provider can help you navigate any side effects you may experience.

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