Genetic Hair Loss: Effects and Risks of Loniten Treatment

Alopecia

Hello Dr.
Cheng, my hair loss is due to hereditary baldness, which is a phenomenon seen in all the men in my family.
Two months ago, I was introduced to Loniten (minoxidil) by a friend, and I have been taking it for two months now.
I have noticed quite a bit of fine hair growth on both of my arms, and there is also an increase in fine hair on my scalp (very fine).
It seems to be having some effect.
After researching the drug, I found that it is used to treat hypertension and promote hair growth.
I would like to know if there are any side effects from long-term use?

Lin, 40~49 year old female. Ask Date: 2003/06/20

Dr. Zheng Lizhen reply Dermatology

The active ingredient of Loniten is Minoxidil.
Precautions during use include: 1.
Generally, (1) monitor fluid balance and body weight.
(2) Observe for symptoms of pericardial effusion.
(3) Patients with renal failure or those on dialysis may require lower doses.
2.
Laboratory tests should be conducted at the start of treatment, including urine analysis, renal function tests, electrocardiogram, chest X-ray, and ultrasound; any abnormalities should be re-evaluated to confirm the Minoxidil therapy.
3.
Allergic reactions may include the occurrence of rashes.
4.
Hematologically, thrombocytopenia and leukopenia are rare.
5.
Gastrointestinal symptoms may include nausea and vomiting.
Contraindications: It is contraindicated in patients with pheochromocytoma, as its antihypertensive effects may stimulate tumor secretion of catecholamines.
Best wishes for health from the Taoyuan Hospital, Department of Dermatology, Ministry of Health and Welfare, Dr.
Cheng Li-Chen.

Reply Date: 2003/06/20

More Info

Loniten, which contains the active ingredient Minoxidil, is primarily known for its use in treating hypertension. However, it has also been found to promote hair growth, making it a popular off-label treatment for genetic hair loss, particularly androgenetic alopecia (male or female pattern baldness). Your experience of noticing fine hair growth on your arms and scalp after two months of treatment is consistent with the effects of Minoxidil, as it can stimulate hair follicles and promote the growth of new hair.

When considering the long-term use of Loniten, it is essential to be aware of potential side effects. While many individuals tolerate Minoxidil well, some may experience adverse effects. Common side effects include:
1. Fluid Retention: Minoxidil can cause the body to retain fluid, leading to swelling in various parts of the body. It's crucial to monitor your weight and any signs of swelling.

2. Cardiovascular Effects: As a vasodilator, Minoxidil can affect heart rate and blood pressure. Patients should be monitored for any changes in heart function, especially if they have pre-existing cardiovascular conditions.

3. Dermatological Reactions: Some users may experience skin irritation, rashes, or allergic reactions. If you notice any unusual skin changes, it is advisable to consult a healthcare provider.

4. Gastrointestinal Issues: Nausea and vomiting can occur, although they are less common.

5. Blood Disorders: Rarely, Minoxidil can lead to blood-related issues such as thrombocytopenia (low platelet count) or leukopenia (low white blood cell count). Regular blood tests may be necessary to monitor these parameters.

6. Hormonal Effects: In some cases, Minoxidil can influence hormonal levels, which may lead to changes in menstrual cycles or other hormonal imbalances.

Given your family history of genetic hair loss, it is understandable that you are seeking effective treatments. While Loniten may provide some benefits in hair growth, it is essential to weigh these against the potential risks. Long-term use should be monitored by a healthcare professional who can assess your overall health and any side effects you may experience.

In addition to Minoxidil, other treatments for genetic hair loss include Finasteride, which works by blocking the conversion of testosterone to dihydrotestosterone (DHT), a hormone linked to hair loss. Combining topical treatments like Minoxidil with oral medications like Finasteride can often yield better results than using either treatment alone. However, it is crucial to discuss these options with your doctor to ensure they are appropriate for your specific situation.

In summary, while Loniten can be effective for promoting hair growth in cases of genetic hair loss, it is essential to be aware of the potential side effects associated with its long-term use. Regular monitoring and consultation with a healthcare provider can help manage any adverse effects and ensure the treatment remains safe and effective for you. If you have concerns about the side effects or the effectiveness of your current treatment regimen, do not hesitate to reach out to your healthcare provider for personalized advice and recommendations.

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