Herpes Simplex Virus Type 2: Testing, Transmission, and Treatment Options - Urology

Share to:

IgG Testing for Type 2 Herpes Simplex Virus (HSV-2) Issues


Hello Doctor: On December 9th (Thursday), I had a blood test for herpes, and when I received the report on December 13th (Monday), my IgG result was 0.32, indicating a negative result.
I would like to ask the doctor the following questions: 1.
I have read that even without symptoms, there can still be transmissibility.
Does a negative test result mean that there is no transmissibility? 2.
What is the approximate duration of the validity of the test results? Can I infer that I was negative for several days before and after December 9th? Is it possible for me to test negative on December 9th and then suddenly become positive one or two days later? 3.
I saw on the CDC website that taking Valaciclovir 500mg daily for an extended period may help keep type 2 herpes negative and non-transmissible.
Has the doctor encountered similar cases in clinical practice? I understand that type 2 herpes cannot be cured, and I am aware that it can still be transmitted even in an asymptomatic state.
To protect my partner, I would like to explore various methods to ensure it is non-transmissible.
Thank you, Doctor.

Peter, 30~39 year old female. Ask Date: 2021/12/17

Dr. Du Shixi reply Urology


Hello, on December 9th (Thursday), I had a blood test for herpes, and when I received the report on December 13th (Monday), the IgG result was 0.32, indicating negative.
I would like to ask the doctor the following questions:
1.
I have read that even without symptoms, there can still be infectiousness.
Does a negative test result mean that there is no infectiousness? --> If the test is accurate, it indicates that I have never had herpes.
2.
What is the timeframe for the test results? Can we estimate that I was negative a few days before and after December 9th? --> The window period is about a few days, and to confirm, I would need to test for IgM.
The IgM test is typically done about two to three weeks after sexual activity, and it can disappear over time.
Is it possible that my IgG result was negative on December 9th and then suddenly increased to positive one or two days later? --> IgG reflects long-term infection; once established, it is unlikely to suddenly spike.
3.
I saw on the CDC website that long-term daily use of Valaciclovir 500mg may help maintain type 2 herpes at a negative status with no infectiousness.
Has the doctor encountered similar cases in clinical practice? --> To my knowledge, there are no clinical cases of long-term use of antiviral medications for herpes.
Wishing you good health.

Reply Date: 2021/12/17

More Info


Understanding Herpes Simplex Virus Type 2 (HSV-2) is crucial for managing health and relationships. HSV-2 is primarily associated with genital herpes, but it can also affect other areas, including the oral cavity. Here, I will address your concerns regarding testing, transmission, and treatment options.

1. Testing and Transmission: Your recent IgG test result of 0.32 indicates a negative result for HSV-2. Generally, a negative IgG test suggests that you have not been infected with the virus. However, it is essential to understand that even if you test negative, there is still a possibility of having been recently infected, especially if you have had potential exposure. The IgG test typically detects antibodies that develop over time, usually taking several weeks to months after exposure. Therefore, if you were infected shortly before the test, it might not have been detected yet.

Regarding transmission, it is true that HSV can be transmitted even when there are no visible symptoms (asymptomatic shedding). However, if your IgG test is negative, it is unlikely that you are capable of transmitting the virus. It’s important to note that the risk of transmission is higher during an active outbreak when sores are present.

2. Timing of Test Results: The timing of your test is crucial. IgG antibodies usually develop within 2 to 12 weeks after infection. Therefore, if you tested negative on December 9, it is reasonable to assume that you were not infected at that time. However, if you had a recent exposure, you might want to consider retesting after a few weeks to confirm your status. It is unlikely that your IgG levels would change dramatically within a couple of days; they typically remain stable unless there is a new infection.

3. Valaciclovir and Suppressive Therapy: Valaciclovir is an antiviral medication commonly used to manage HSV infections. Studies have shown that daily suppressive therapy with Valaciclovir can significantly reduce the risk of transmission to sexual partners, especially in individuals with a known HSV-2 infection. While it does not cure the virus, it can help manage outbreaks and reduce asymptomatic shedding. In clinical practice, many patients have successfully used suppressive therapy to lower their risk of transmitting the virus to their partners.

In conclusion, based on your negative IgG test result, it appears that you are not currently infected with HSV-2. However, if you have concerns about potential exposure or symptoms, it is advisable to consult with a healthcare provider for further evaluation and possibly retesting. If you are considering suppressive therapy with Valaciclovir for peace of mind and to protect your partner, discussing this option with your healthcare provider is a good step. They can provide personalized advice based on your health history and circumstances.

Remember, maintaining open communication with your partner about sexual health is essential, and taking preventive measures can help ensure both of your well-being.

Similar Q&A

Understanding Herpes Simplex Virus: Risks, Transmission, and Emotional Impact

I was diagnosed with a herpes simplex virus type 1 and 2 infection at Taichung Teaching Hospital in May 1993, but I had suspected it earlier. In November 1990, I had blood tests done at a private laboratory, which informed me that I was not infected, leading me to feel reassured....


Dr. Jiang Zheen reply Dermatology
Herpes is only contagious during an outbreak, and transmission occurs through direct contact with the lesions. At other times, it is not contagious. As long as you maintain a normal lifestyle and reduce stress, you can confidently get married and have children. I also have oral h...

[Read More] Understanding Herpes Simplex Virus: Risks, Transmission, and Emotional Impact


Understanding Herpes: Symptoms, Transmission, and Prevention Strategies

Previously, I had some blisters on my genitals and went to the hospital for treatment. It was diagnosed as herpes. After treatment, there are no visible symptoms. However, I was still concerned and had a blood test done. The results showed that the herpes simplex virus type 1 (HS...


Dr. Hong Zhengsheng reply Dermatology
Hello, Chen: Due to the diverse sexual lifestyles of modern individuals, there are no strict limitations on where herpes simplex virus type 1 and type 2 can manifest. Blood tests are used to check for antibodies, but they must be interpreted in conjunction with clinical symptoms ...

[Read More] Understanding Herpes: Symptoms, Transmission, and Prevention Strategies


Understanding HSV-2: Testing, Symptoms, and Transmission Concerns

Dear Dr. Hsu, I would like to consult you regarding my condition and some questions I have. I hope you can take the time to respond: 1) I have only had one sexual partner, my wife. However, in 1998, I had an incident of unprotected sex after drinking, and three months later, I ...


Dr. Xu Weikai reply Urology
SadMan: Hello, even if you are infected with herpes, so what? There is really no need to worry unless your immune system is compromised, such as in the case of HIV patients; otherwise, treatment is not necessary. Note: In Taiwan, over 50% of adults are carriers, just not showing ...

[Read More] Understanding HSV-2: Testing, Symptoms, and Transmission Concerns


Understanding Herpes Simplex Virus Type 2: Transmission and Blood Donation FAQs

Hello, doctor. I have the following questions: 1.) Is it true that herpes simplex virus type 2 (HSV-2) is transmitted through contact, and can it still be transmitted when there are no symptoms? 2.) Can a person who has had HSV-2 donate blood? 3.) HSV-2 is most contagious before ...


Dr. Li Xinyi reply Urology
Whether it is type 1 or type 2, in all cases of symptoms (in recurrent cases, some patients exhibit almost no symptoms), infectiousness can occur shortly before the symptoms appear, making it difficult to rely on symptoms to prevent infection. Blood donation is possible.

[Read More] Understanding Herpes Simplex Virus Type 2: Transmission and Blood Donation FAQs


Related FAQ