Elevated hs-CRP Levels: Heart Risks and Gastrointestinal Impact - Cardiology

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Abnormal health check report?


This year, the company health check included out-of-pocket cardiac-related tests, and the result for high-sensitivity C-reactive protein (hs-CRP) was extremely high at 3.248 (with a reference value of <0.1).
I found online that this level indicates a high risk for myocardial infarction.
However, I recalled that on the day of the test, I had gastroenteritis and had been experiencing diarrhea for two days without seeking medical attention.
Since all other test results were normal except for this elevated hs-CRP, I would like to ask the doctor if the gastroenteritis could have influenced the result.
Would the doctor recommend a follow-up appointment to retest?

Judy, 30~39 year old female. Ask Date: 2022/01/13

Dr. He Dongjin reply Cardiology


Hello, it is likely that you are experiencing gastroenteritis, which may not necessarily be related to a myocardial infarction.
If you are concerned, it would be best to return for a check-up.
Take care, and we at Changhua Hospital are here for you.

Reply Date: 2022/01/13

More Info


Elevated levels of high-sensitivity C-reactive protein (hs-CRP) can indeed raise concerns regarding cardiovascular health, particularly in the context of potential myocardial infarction (heart attack) risk. The hs-CRP test is a marker of inflammation in the body, and elevated levels can indicate an increased risk of cardiovascular events. In your case, a level of 3.248 mg/L is significantly above the normal threshold (typically <0.1 mg/L), which can be alarming.

However, it is essential to consider the context in which this elevated level was measured. You mentioned experiencing gastrointestinal issues, specifically diarrhea, for two days prior to the test. Gastrointestinal infections or inflammation can indeed lead to elevated CRP levels, as the body responds to inflammation regardless of its source. Infections, autoimmune diseases, and even certain chronic conditions can cause a spike in CRP levels. Therefore, it is plausible that your gastrointestinal condition could have contributed to the elevated hs-CRP reading.

Given that other tests returned normal results, it would be prudent to discuss your situation with your healthcare provider. They may suggest retesting your hs-CRP levels after your gastrointestinal symptoms have resolved to determine if the elevation was a temporary response to inflammation from your gastrointestinal issues or if it reflects a more chronic inflammatory state that could be related to cardiovascular risk.

In addition to retesting, your doctor might consider a comprehensive evaluation of your cardiovascular risk factors. This includes assessing your family history, lifestyle factors (such as diet, exercise, and smoking), and other laboratory tests that can provide a clearer picture of your heart health. If there are additional risk factors present, such as hyperlipidemia or hypertension, your healthcare provider may recommend lifestyle modifications or medications to mitigate these risks.

It is also worth noting that while elevated hs-CRP levels can indicate increased cardiovascular risk, they are not definitive on their own. They should be interpreted in conjunction with other clinical findings, including imaging studies (like echocardiograms or stress tests), and patient symptoms. For instance, if you have chest pain or other symptoms suggestive of heart disease, further evaluation such as a stress test or coronary angiography may be warranted.

In conclusion, while your elevated hs-CRP level is concerning, it is crucial to consider the context of your gastrointestinal symptoms. A follow-up with your healthcare provider to discuss retesting and a comprehensive cardiovascular risk assessment is advisable. This approach will help clarify whether the elevated hs-CRP is a transient response to inflammation or indicative of a more significant underlying issue that requires attention. Always prioritize open communication with your healthcare provider to ensure that your health concerns are adequately addressed.

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