Managing GERD: Concerns About Taking Hiccup Relief Before Bed - Gastroenterology and Hepatology

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Taking Xituitong 60 before bedtime has significantly worsened my stomach bloating?


Hello, two weeks ago I was diagnosed with gastroesophageal reflux disease (GERD) after an endoscopy, which indicated that my lower esophageal sphincter is slightly relaxed, but not severely.
Prior to the diagnosis, I had been taking different proton pump inhibitors (PPIs) from various clinics for nearly a month.
After the endoscopy, my doctor prescribed me Hicet 60 to take before bed, as I was still experiencing reflux symptoms at night despite taking a 30 mg PPI in the morning.
Since starting Hicet 60, my pre-existing bloating has worsened, especially in the afternoon and around dinner time.
My current food intake is about half of what it used to be, and I am constantly searching for foods that are supposedly less likely to cause bloating.
However, I still need to drink a small bottle of yogurt (about 200 cc) an hour after dinner to alleviate the bloating somewhat.
Previously, if I couldn't find relief, taking Hicet 60 before bed would still lead to acid reflux in the middle of the night.
I am unsure if taking Hicet 60 has reduced my stomach acid, leading to indigestion.
By the afternoon, I often find that my food has not fully digested.
Are there any alternative medications to PPIs that I can take when I am uncomfortable? Thank you.

Mr. Huang, 40~49 year old female. Ask Date: 2022/01/20

Dr. Zhang Kebin reply Gastroenterology and Hepatology


Hello! Please follow the prescribed medication.
If your discomfort does not improve after treatment or if new symptoms arise, please return for an evaluation.
Thank you!

Reply Date: 2022/01/20

More Info


Managing gastroesophageal reflux disease (GERD) can be quite challenging, especially when dealing with medication side effects and dietary restrictions. Your experience with the PPI (proton pump inhibitor) medication and the subsequent increase in bloating is not uncommon. Let’s break down your concerns and explore potential solutions.

Firstly, it's important to understand that PPIs like the one you mentioned, "喜胃通" (likely a brand name for a PPI), work by reducing the amount of stomach acid produced. This can help alleviate symptoms of GERD, such as heartburn and acid reflux. However, the reduction in stomach acid can sometimes lead to digestive issues, including bloating and delayed gastric emptying, as you have experienced. When the stomach acid is reduced, it can impair the digestion of food, leading to feelings of fullness or bloating, especially if food is not being broken down properly.

You mentioned that you are experiencing increased bloating, particularly in the afternoon and evening, and that you have reduced your food intake significantly. This could be a response to your body’s adjustment to the PPI, but it may also indicate that your diet needs further modification. Foods that are high in fat, spicy, or acidic can exacerbate GERD symptoms, so focusing on a bland diet with smaller, more frequent meals might help. Additionally, avoiding carbonated beverages and high-fiber foods that can cause gas may also be beneficial.

Regarding your concern about whether the PPI is causing your digestive issues, it is possible. Some patients report that while PPIs effectively reduce acid reflux, they may also lead to symptoms of indigestion or bloating. If you find that the bloating persists or worsens, it may be worth discussing with your healthcare provider the possibility of adjusting your medication or exploring alternative treatments.

As for alternatives to PPIs, there are several options available. H2 blockers, such as ranitidine or famotidine, can reduce stomach acid production but may not be as effective as PPIs for severe GERD. Antacids can provide quick relief for heartburn but do not prevent acid production. Additionally, prokinetic agents, which help with gastric emptying, might be considered if delayed gastric emptying is a concern.

You also mentioned taking a probiotic (the yogurt drink) to help with bloating. Probiotics can be beneficial for gut health and may help alleviate some digestive symptoms. However, it’s essential to choose a probiotic that is appropriate for your specific symptoms. Some probiotics can produce gas as a byproduct of fermentation, which might exacerbate bloating in some individuals.

Lastly, regarding your experience with nighttime reflux despite taking medication, it’s crucial to consider lifestyle modifications alongside medication. Elevating the head of your bed, avoiding eating large meals close to bedtime, and steering clear of trigger foods in the evening can significantly reduce nighttime symptoms.

In summary, while PPIs can be effective for managing GERD, they may also lead to digestive discomfort in some patients. It’s essential to work closely with your healthcare provider to monitor your symptoms and make necessary adjustments to your treatment plan. Exploring dietary changes, considering alternative medications, and implementing lifestyle modifications can all contribute to better management of your GERD symptoms. If your symptoms persist or worsen, don’t hesitate to seek further evaluation from a gastroenterologist.

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