Thyroid Medication for Pregnant Women: Concerns and Considerations - Internal Medicine

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Pregnant women with thyroid conditions taking Antithyroid medication?


Hello Doctor,
I would like to briefly summarize my medical history.
During middle school, I developed benign thyroid nodules and underwent a partial thyroidectomy, removing three-quarters of my thyroid.
My thyroid blood tests have consistently shown normal results.
In August of last year, my blood tests showed T3: 84.30, Thyroid Stimulating Hormone (TSH) Immunoassay: 4.05, Free Thyroxine (FT4) Immunoassay: 1.46, and Anti-TPO: <9.00.
My attending physician prescribed me four tablets of Antithyroid medication (likely referring to a specific brand) per week, and I returned for a follow-up four months later.
The results then were T3: 111.00, TSH Immunoassay: 2.20, FT4 Immunoassay: 1.46, and Anti-TPO: 9.86.
At that time, I was already four weeks pregnant, so the doctor increased my dosage to eight tablets of Antithyroid medication per week.
I have a few questions I would like to ask:
1.
Since my prenatal vitamins contain 130 micrograms of iodine, my doctor advised me to avoid seafood.
Will this affect fetal development? As a mother, I tend to worry a lot and would like to seek multiple opinions.

2.
After starting the Antithyroid medication, I began to develop rashes after eating seafood, and now that I am pregnant, I experience diarrhea the day after consuming seafood.
Are there any similar cases? I am unsure if this is due to starting the Antithyroid medication or if my body has changed since turning thirty.

3.
I do not exhibit any obvious symptoms of hypothyroidism.
Does my situation classify me as a patient with hypothyroidism?
I look forward to your response.
Thank you.

Xiao Yu, 30~39 year old female. Ask Date: 2022/01/24

Dr. Hong Yuanbin reply Internal Medicine


Hello,
1.
The nutritional benefits of seafood can be obtained from other food sources, so it is advisable to temporarily avoid seafood.
This should not significantly impact fetal development.

2.
All seafood contains different components, so it is quite common to suddenly discover an allergic reaction to certain types of seafood.
This is likely not directly related to the medications you are taking.

3.
Based on your blood test results, you appear to have mild hypothyroidism, which typically does not present with noticeable symptoms.
Thank you for your inquiry.

Reply Date: 2022/01/24

More Info


When it comes to thyroid medication during pregnancy, particularly for women with a history of thyroid issues, there are several important considerations to keep in mind. Your situation, involving a history of benign thyroid nodules and partial thyroidectomy, adds complexity to your management during pregnancy.
1. Thyroid Hormone Levels and Pregnancy: It is crucial to maintain appropriate thyroid hormone levels during pregnancy, as both hypothyroidism (low thyroid hormone levels) and hyperthyroidism (high thyroid hormone levels) can have adverse effects on both the mother and the developing fetus. The thyroid hormone levels you provided indicate that you are being monitored closely, which is essential. The increase in your medication dosage to eight tablets of Levothyroxine (昂特欣錠) per week suggests that your healthcare provider is aiming to ensure that your thyroid levels remain stable, particularly as pregnancy can alter thyroid hormone requirements.

2. Iodine Intake: Iodine is a critical nutrient for fetal development, particularly for brain development. The recommendation to avoid seafood due to the iodine content in your prenatal vitamins is a common precaution, especially if there is a concern about excessive iodine intake. However, iodine deficiency can also pose risks. It is essential to strike a balance. Discussing your iodine intake with your healthcare provider is vital, as they may recommend monitoring your iodine levels or adjusting your dietary restrictions based on your specific needs.

3. Allergic Reactions and Dietary Changes: The symptoms you describe, such as developing a rash after consuming seafood and experiencing diarrhea, could be indicative of an allergy or intolerance rather than a direct effect of the Levothyroxine. Food sensitivities can develop at any stage of life, and pregnancy can sometimes exacerbate these issues due to hormonal changes. It is advisable to consult with an allergist or your healthcare provider to determine if you have developed a seafood allergy or if there are other dietary factors at play.

4. Thyroid Function Assessment: Your lab results indicate that you have normal levels of T3 and T4, along with a TSH level that is within the normal range, suggesting that you are not currently experiencing hypothyroidism. However, the need for medication indicates that your thyroid function may not be fully adequate without supplementation. It is essential to continue regular monitoring of your thyroid function throughout your pregnancy, as the demands for thyroid hormones increase during this time.

5. Potential Risks to the Fetus: Uncontrolled thyroid dysfunction can lead to complications such as preterm birth, low birth weight, and developmental issues in the child. Therefore, it is critical to adhere to your prescribed medication regimen and maintain regular follow-ups with your healthcare provider. If you have concerns about the effects of Levothyroxine on your fetus, discussing these with your obstetrician or endocrinologist can provide clarity and reassurance.

6. Communication with Healthcare Providers: Given the complexities of managing thyroid conditions during pregnancy, it is vital to maintain open communication with both your obstetrician and endocrinologist. They can work together to ensure that your thyroid levels are optimal and that any potential risks are managed effectively.

In summary, while managing thyroid medication during pregnancy can be challenging, with careful monitoring and communication with your healthcare team, you can help ensure a healthy pregnancy for both you and your baby. Always consult your healthcare provider before making any changes to your medication or diet, and ensure that you are receiving the appropriate support throughout your pregnancy journey.

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