Using Vaginal Suppositories During Pregnancy: Safety and Guidelines - Obstetrics and Gynecology

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Vaginal suppository usage


Hello, Doctor.
I am currently 19 weeks pregnant and have been experiencing itching in my private area.
Therefore, I visited the obstetrics and gynecology department yesterday (January 25).
After examination, it was found that I have a mild vaginal yeast infection.
The doctor administered a Nystatin vaginal suppository (Weda) and prescribed two additional suppositories for me to use before bedtime on January 26 and 27.
However, on the night of January 25, I forgot that I had already used a suppository, so I inserted another one.
I would like to ask if this will have any effects.
Should I return to the clinic to request an additional Nystatin suppository? Additionally, will this have any impact on the fetus? What would be the best course of action? Thank you for your assistance.

Sunny Yang, 30~39 year old female. Ask Date: 2022/01/26

Dr. Wu Xianghui reply Obstetrics and Gynecology


Nystatin by Guangtian Hospital website: Category A: A controlled study in pregnant women during the first trimester (the first three months) showed that the drug is not harmful to the fetus, and there is no evidence indicating any risk during the later trimesters of pregnancy.

Reply Date: 2022/01/26

More Info


Using vaginal suppositories during pregnancy can be a common practice, especially when addressing issues like yeast infections, which can occur due to hormonal changes and other factors during pregnancy. In your case, you were prescribed Nystatin, an antifungal medication that is generally considered safe for use during pregnancy.

Safety of Nystatin During Pregnancy
Nystatin is classified as a Category C drug by the FDA, which means that while animal reproduction studies have shown an adverse effect on the fetus, there are no adequate and well-controlled studies in pregnant women. However, it is often prescribed because the benefits may outweigh the risks, especially when treating infections that could cause more significant complications if left untreated.

Overuse of Nystatin
Regarding your concern about using an extra dose of Nystatin, while it is generally recommended to follow the prescribed dosage, taking an additional dose accidentally is unlikely to cause significant harm. Nystatin is not absorbed into the bloodstream in significant amounts when used vaginally, which minimizes the risk of systemic side effects. However, it is always best to consult your healthcare provider if you have concerns about medication dosages or if you experience any unusual symptoms after using the medication.


Impact on the Fetus
As for the impact on your fetus, Nystatin is considered safe, and there is no substantial evidence to suggest that it poses a risk to fetal development when used as directed. The primary concern during pregnancy is to treat infections effectively to prevent complications such as preterm labor or other issues that could arise from untreated infections.


Recommendations
1. Consult Your Doctor: Since you have concerns about the extra dose, it would be prudent to contact your healthcare provider. They can provide personalized advice based on your medical history and current situation.

2. Follow Prescribed Dosage: In the future, try to keep a medication schedule or reminder to avoid missing or doubling doses. This can help ensure you are using the medication as prescribed.

3. Monitor Symptoms: Keep an eye on your symptoms. If you notice any worsening of your condition or new symptoms, inform your healthcare provider promptly.

4. Maintain Communication: Always feel free to discuss any concerns regarding medications during pregnancy with your healthcare provider. They can provide reassurance and guidance tailored to your specific needs.


Conclusion
In summary, using Nystatin vaginal suppositories during pregnancy is generally safe, and an accidental extra dose is unlikely to cause harm. However, maintaining open communication with your healthcare provider is essential for managing your health and the health of your baby effectively. Always prioritize your comfort and peace of mind by discussing any concerns with your doctor.

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