Hepatitis C Test Results: What You Need to Know - Gastroenterology and Hepatology

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Understanding Hepatitis C test results can be quite complex, especially when interpreting the significance of antibody levels and their changes over time. Based on the information provided, let's break down your questions regarding your Hepatitis C (HCV) antibody test results.

1. Confirmation of Hepatitis C Status: The presence of antibodies to HCV (Anti-HCV) indicates that you have been exposed to the virus at some point. However, it does not necessarily mean you are currently infected. The key to determining your current infection status lies in the HCV RNA test, which detects the actual virus in your blood. If your most recent test shows an Anti-HCV level of 0.077 COI (which is below the threshold for positivity), it suggests that you may not have an active infection. However, it is essential to consult with your healthcare provider for a definitive diagnosis, as they may recommend further testing, such as an HCV RNA test, to confirm that there is no active infection.

2. Interpreting Different Units: The discrepancy in units (S/CO vs. COI) can indeed be confusing. S/CO (Signal-to-Cutoff ratio) and COI (Cutoff Index) are different methods of reporting antibody levels, and they may have different thresholds for positivity. Generally, a result above the cutoff value indicates a positive result, while a result below indicates a negative result. It is crucial to refer to the specific reference ranges provided by the laboratory that performed your tests, as these ranges can vary. Your healthcare provider can help interpret these results in the context of your overall health and history.

3. Rising Antibody Levels: The slight increase in your Anti-HCV levels from 0.067 COI to 0.077 COI over the years may not be clinically significant, especially if both values are still considered negative according to the laboratory's reference range. However, any upward trend in antibody levels should be monitored. It is essential to discuss this with your healthcare provider, who may recommend regular follow-up testing to ensure that there are no changes in your HCV status over time.

In summary, while your current test results suggest that you may not have an active Hepatitis C infection, it is crucial to follow up with your healthcare provider for further evaluation and possibly additional testing. They can provide personalized recommendations based on your medical history and the specifics of your test results. Regular monitoring is essential, especially if there are any changes in your health or if you have risk factors for Hepatitis C.