Persistent Leg Discomfort After COVID-19 Vaccination: When to Seek Help? - Internal Medicine

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Persistent soreness and numbness in the right calf after receiving the COVID-19 vaccine?


Hello, doctor.
I received my third dose of Moderna, and starting the next day, I have been experiencing soreness and numbness in my right calf and foot.
This sensation has been persistent, lasting for several hours and occurring multiple times a day.
(Previously, after the first dose of AstraZeneca, I experienced intermittent numbness that would come and go throughout my body.) It has now been three days of this soreness and numbness.
There are no visible spots on my skin, and I do not feel any weakness in my leg.
Should I seek medical attention, or is it advisable to wait and see if any other symptoms develop? Thank you.

Lun, 30~39 year old female. Ask Date: 2022/02/27

Dr. Hong Yuanbin reply Internal Medicine


Hello, what you described are indeed potential symptoms of the vaccine.
It is recommended to rest for a few days, and you should gradually improve.
If there is no improvement or if the symptoms continue to worsen, then medical attention is necessary.
Thank you for your inquiry.

Reply Date: 2022/02/27

More Info


After receiving the third dose of the Moderna vaccine, you are experiencing persistent discomfort in your right calf and foot, characterized by a sensation of soreness and numbness that has lasted for several days. It’s understandable to be concerned about these symptoms, especially after vaccination, as many individuals have questions about what constitutes a normal reaction versus something that may require medical attention.

Firstly, it is important to note that vaccine-related side effects can vary widely among individuals. Common side effects of COVID-19 vaccines, including Moderna, typically include pain at the injection site, fatigue, headache, muscle pain, chills, fever, and nausea. These symptoms usually resolve within a few days. However, some individuals may experience less common side effects, such as the sensations you are describing.

The persistent soreness and numbness in your leg could be a result of several factors. It’s possible that this discomfort is related to the vaccine, as some people report unusual sensations in their limbs following vaccination. This could be due to an immune response or inflammation in the body. However, it is also important to consider other potential causes, such as:
1. Nerve Irritation or Compression: Sometimes, positions during sleep or daily activities can lead to temporary nerve compression, which can cause numbness or tingling sensations.
2. Circulatory Issues: If there are any underlying circulatory problems, they could be exacerbated by the vaccine or by changes in activity levels post-vaccination.

3. Muscle Strain: If you have engaged in any physical activity that may have strained your calf muscles, this could also explain the soreness.

Given that your symptoms have persisted for three days without any improvement, it would be prudent to seek medical advice. Here are some guidelines on when to seek help:
- Duration of Symptoms: If symptoms last longer than a few days without improvement, it’s advisable to consult a healthcare professional.

- Severity of Symptoms: If the discomfort worsens or if you start experiencing additional symptoms such as swelling, redness, warmth in the affected area, or if you develop weakness in the leg, you should seek medical attention promptly.

- Impact on Daily Activities: If the discomfort is affecting your ability to perform daily activities or is causing significant distress, it’s a good idea to consult a healthcare provider.

- Underlying Health Conditions: If you have any pre-existing conditions that could be related to your symptoms (such as vascular issues, diabetes, or neurological conditions), it’s wise to discuss these with your doctor.

In conclusion, while it is possible that your symptoms are a benign reaction to the vaccine, it is always better to err on the side of caution. Consulting with a healthcare professional can provide you with peace of mind and ensure that any underlying issues are addressed. They may recommend further evaluation, such as a physical examination or imaging studies, to rule out any serious conditions. Remember to keep track of any changes in your symptoms and communicate these to your healthcare provider.

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