Can Patients with Favism Safely Use Koshuyin Eye Drops? - Ophthalmology

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Can patients with G6PD deficiency use Keshuyan eye drops?


Previously, I had eye inflammation and consulted a doctor.
The doctor mentioned that my intraocular pressure was elevated (20 in the left eye, 21 in the right eye), so I couldn't be prescribed steroid eye drops (I was usually prescribed Foxone).
Later, I was given Keshuyin, but it caused me dizziness and headaches.
After researching online, I found out that Keshuyin eye drops should be used with caution in patients with G6PD deficiency! Additionally, the doctor later prescribed Chloramphenicol.
Is this an eye drop that is rarely used nowadays? Its side effects seem quite concerning, so I am hesitant to use it! Lastly, I would like to know if there are any eye drops available for someone with elevated intraocular pressure and G6PD deficiency during episodes of eye inflammation?

Xiao Ke, 50~59 year old female. Ask Date: 2022/03/03

Dr. Gao Pilin reply Ophthalmology


Hello, Xiao Ke: Chloramphenicol is a commonly used medication.
Side effects are also uncommon.
The package insert for Keshuyan medication indicates that caution should be exercised in patients with favism.
If elevated intraocular pressure is not caused by steroids, steroids can still be used for inflammation.
Besides these medications, there are other options available, so please rest assured.

Reply Date: 2022/03/03

More Info


Patients with Favism, a condition characterized by a deficiency in the enzyme glucose-6-phosphate dehydrogenase (G6PD), must be cautious when using certain medications, including eye drops. The concern arises from the potential for certain compounds in medications to trigger hemolytic anemia in individuals with this condition.
Koshuyin eye drops, which may contain various active ingredients, should be approached with caution. It is essential to consult with a healthcare provider before using any new medication, especially for patients with underlying conditions like Favism. The specific ingredients in Koshuyin eye drops should be reviewed to determine if they pose any risk. If the eye drops contain any known triggers for hemolytic anemia, they should be avoided.

Regarding the use of corticosteroids, it is understandable that your doctor refrained from prescribing them due to elevated intraocular pressure (IOP). Corticosteroids can increase IOP, which is a concern for patients with pre-existing conditions. The alternative medication, Koshuyin, may have been prescribed to manage inflammation without the risks associated with steroids. However, if you experienced dizziness and headaches, it is crucial to report these side effects to your doctor, as they may indicate an adverse reaction or intolerance to the medication.

Chloramphenicol, another medication mentioned, is indeed less commonly used today due to its potential side effects, including serious ones like aplastic anemia. While it can be effective for bacterial infections, its use is generally reserved for specific situations where other antibiotics are not suitable. If you have concerns about using chloramphenicol, discuss them with your healthcare provider. They can provide guidance on the risks versus benefits in your particular case.

For patients with elevated IOP and Favism experiencing eye inflammation, there are still options available. Non-steroidal anti-inflammatory eye drops (NSAIDs) may be considered, as they do not typically affect IOP and are generally safe for G6PD-deficient patients. Additionally, artificial tears can help alleviate dryness and irritation without the risks associated with medicated drops.

In summary, if you have Favism and are experiencing eye inflammation with elevated IOP, it is crucial to work closely with your healthcare provider to find safe and effective treatment options. Always disclose your full medical history and any concerns about medications to ensure you receive the best care tailored to your needs. If you are ever in doubt about a medication, especially with your specific health conditions, seeking a second opinion or further clarification from your healthcare provider is always a wise choice.

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