Your HIV Test Results: What You Need to Know - Internal Medicine

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HIV testing issues


Hello, doctor.
I apologize for bothering you, but I would like to ask you a few questions.
Recently, I underwent testing for sexually transmitted infections, including syphilis, gonorrhea, and HIV, and all results were negative.
However, I have some concerns regarding the nomenclature of the HIV test.
I don't quite understand the report, which states: Test item: HIV I.II O/p24Ag; HIV screening test result: negative.
I found online that most people are tested with the HIV Ag/Ab Combo, which tests for both antigens and antibodies.
Does this mean that I only tested for the antigen and did not test for the antibodies? This has made me a bit anxious after the tests.
Doctor, do you think I need to get retested? Note: It has been almost a year since my last sexual encounter, which was in March of last year.

Ning, 20~29 year old female. Ask Date: 2022/03/07

Dr. Hong Yuanbin reply Internal Medicine


Hello, the main concern is the potential for a window period and sensitivity issues with the tests.
The HIV Ag/Ab Combo has a higher sensitivity, but the HIV I/II O/p24Ag test is also quite reliable.
Overall, your chances of being negative are very high.
However, if you truly believe your risk is significant, you may consider retesting in 3 to 6 months for confirmation.
Thank you for your question.

Reply Date: 2022/03/07

More Info


Understanding your HIV test results can be a source of anxiety, especially when there are uncertainties about the type of tests conducted and their implications. It’s important to clarify the details surrounding your HIV testing to alleviate your concerns.

From your description, it seems that you underwent an HIV test that specifically checked for HIV I, II, and p24 antigen. The p24 antigen is a protein that is part of the HIV virus and can be detected in the blood shortly after infection, often before antibodies are produced. This is why tests that include p24 antigen are useful for early detection of HIV. However, the combination tests, often referred to as HIV Ag/Ab Combo tests, check for both the p24 antigen and antibodies to HIV (both HIV-1 and HIV-2). This dual approach increases the accuracy of the test, especially in the early stages of infection.

Given that your test result was negative, it indicates that either there was no HIV infection at the time of testing or that the virus was not present in detectable levels. Since you mentioned that your last sexual encounter was nearly a year ago, it is highly unlikely that you would have contracted HIV during that time if you have not engaged in any high-risk behaviors since then.

To address your concerns about whether you need to retest: if your last sexual encounter was in March of last year and you have had a negative test result since then, it is generally considered safe to conclude that you are not infected with HIV. The window period for HIV tests varies depending on the type of test used. For most modern tests, including the HIV Ag/Ab Combo, the window period is typically around 2 to 4 weeks for initial detection, and up to 3 months for conclusive results. Since you are approaching a year since your last potential exposure, you are well beyond the window period.

If you still feel anxious or uncertain, it may be beneficial to discuss your concerns with a healthcare provider. They can provide reassurance and, if necessary, recommend a follow-up test for your peace of mind. It’s also worth noting that regular testing is a good practice, especially if you engage in new sexual relationships or have any changes in your sexual health.

In summary, based on your negative test results and the time elapsed since your last sexual encounter, it is unlikely that you have HIV. However, if you have lingering doubts, consulting with a healthcare professional for further advice and possibly a follow-up test could help ease your concerns. Regular health check-ups and open communication with your healthcare provider are key components of maintaining sexual health.

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