Helicobacter Pylori Treatment: Antibiotics and Recovery Time - Gastroenterology and Hepatology

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Helicobacter pylori treatment


Hello, doctor.
I took an antibiotic prescribed by my ophthalmologist, Cephalexin 500mg (CEPHALEXIN CAPSULES "S.T."), the night before my gastroscopy.
I only found out afterward that antibiotics should not be taken before testing for Helicobacter pylori.
Will this affect the results? During the gastroscopy, a sample was taken from my stomach, and at my follow-up appointment, it was found that I have a mild Helicobacter pylori infection.
The outpatient doctor said I need to undergo treatment for over two months before retesting for Helicobacter pylori.
Is such a long duration of treatment necessary? I also have mild erosion at the cardia and gastritis, but no polyps.
For the first week, I was prescribed AMOXICILLIN 500MG/CAP, taking two capsules after breakfast and dinner; PANTOPRAZOLE G.R.
40MG/TAB, one tablet before breakfast and dinner; PRIMPERAN F.C.
5MG/TAB, one tablet before each meal; and KASCOAL 50MG/TAB, one tablet before each meal.
If I experience severe side effects, can I stop the medication?

Nana, 30~39 year old female. Ask Date: 2022/03/19

Dr. Cai Anshun reply Gastroenterology and Hepatology


Hello: The treatment for Helicobacter pylori is mostly a quadruple therapy for 1 to 2 weeks (PPI + Amoxicillin + Clarithromycin + Metronidazole).
The physician mentioned a 2-month treatment, which likely refers to taking a single gastric medication for 2 months, not the Helicobacter pylori medications for 2 months.
If there are no allergies, such as a rash, it is not recommended to discontinue the medication.
If you have any issues with the medication, it is advisable to discuss them with your physician and not to stop the medication on your own.
Changhua Hospital cares about your health.
Dr.
Tsai An-shun.

Reply Date: 2022/03/19

More Info


When it comes to treating Helicobacter pylori (H. pylori) infections, understanding the medication regimen, potential side effects, and recovery timeline is crucial for effective management. Based on your inquiry, let's break down the key aspects of your treatment and address your concerns.


1. Impact of Prior Antibiotic Use
Taking an antibiotic like Cephalexin the night before your endoscopy may affect the results of your H. pylori test. Antibiotics can suppress bacterial growth, potentially leading to false-negative results. However, since your test indicated a mild presence of H. pylori, it suggests that the bacteria were still detectable despite the prior antibiotic use. It’s important to inform your healthcare provider about any medications taken prior to testing, as this can influence treatment decisions.


2. Treatment Duration
The standard treatment for H. pylori typically lasts between 10 to 14 days, depending on the specific antibiotic regimen prescribed. In your case, the doctor has recommended a treatment duration of over two months, which may seem longer than usual. This extended period could be due to the presence of gastritis and the need for thorough eradication of the bacteria, especially if there are complications like mucosal damage. It’s essential to follow your doctor's advice and complete the full course of treatment to ensure the best chance of eradication.


3. Medication Regimen
Your current regimen includes:
- Amoxicillin 500 mg: This antibiotic is effective against H. pylori and is typically taken after meals to enhance absorption and minimize gastrointestinal side effects.

- Pantoprazole 40 mg: A proton pump inhibitor (PPI) that reduces stomach acid, helping to heal the gastric lining and improve the effectiveness of antibiotics.

- Primperan (Metoclopramide) 5 mg: This medication helps with nausea and can be taken before meals.

- Kascoal: This is likely a protective agent for the gastric mucosa.


4. Managing Side Effects
It’s common to experience side effects from antibiotics, such as nausea, diarrhea, or abdominal discomfort. If you encounter severe side effects, it’s crucial to communicate with your healthcare provider before making any decisions about stopping the medication. They may suggest adjusting the dosage or switching to a different medication to alleviate discomfort while still effectively treating the infection.


5. Recovery and Follow-Up Testing
After completing the treatment, your doctor may recommend a follow-up test to confirm that the H. pylori infection has been eradicated. This is typically done through a breath, stool, or endoscopic biopsy test. The timing of this follow-up is essential; it’s usually advised to wait at least four weeks after completing antibiotic therapy to ensure accurate results.


6. Dietary Considerations
While undergoing treatment, it’s advisable to maintain a bland diet that avoids spicy, acidic, or irritating foods that may exacerbate gastric discomfort. Incorporating probiotics, such as yogurt or supplements, can also be beneficial in restoring gut flora, although you should consult your doctor about the best timing for these.


Conclusion
In summary, your treatment for H. pylori involves a combination of antibiotics and a proton pump inhibitor, which is standard practice. While the duration may seem extended, it’s essential to adhere to your doctor’s recommendations for the best outcome. Always communicate any side effects you experience, and do not hesitate to reach out to your healthcare provider for guidance throughout your treatment journey. Following these steps will help ensure effective management of your H. pylori infection and promote healing of your gastric lining.

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