Does Skipping Morning Doses of Antibiotics Affect Their Effectiveness? - Internal Medicine

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Antibiotic Consultation


I was scratched by a cat, and the doctor prescribed me Norfloxacin, which is an antibiotic.
I have only been taking it in the evenings with food for the past two days and haven't taken it in the mornings.
Will this affect its effectiveness?

A-Ming, 20~29 year old female. Ask Date: 2022/03/28

Dr. Hong Yuanbin reply Internal Medicine


Hello, what you are referring to is likely Norfloxacin enteric-coated tablets.
This antibiotic is typically taken twice a day, so it is usually administered once in the morning and once in the evening.
Your method of use should not affect its efficacy.
Thank you for your question.

Reply Date: 2022/03/28

More Info


Skipping morning doses of antibiotics can significantly affect their effectiveness, particularly if the medication is prescribed for a specific infection. Antibiotics, like the one you mentioned (likely referring to "Cefuroxime" or a similar medication), work best when taken consistently at the prescribed intervals. This ensures that the drug maintains a therapeutic level in your bloodstream, which is crucial for effectively combating the bacteria causing the infection.

When you skip doses, especially in the case of antibiotics, you risk allowing the bacteria to survive and potentially develop resistance to the medication. This can lead to a situation where the antibiotic becomes less effective or even ineffective against the bacteria, making it harder to treat the infection. In some cases, this can result in the need for a stronger antibiotic or a longer course of treatment.

For antibiotics that are taken multiple times a day, such as every 12 hours, it is essential to adhere to the schedule as closely as possible. If you miss a dose, the general guideline is to take it as soon as you remember, unless it is almost time for your next dose. In that case, you should skip the missed dose and continue with your regular schedule. Never double up on doses to make up for a missed one, as this can increase the risk of side effects and toxicity.

In your case, since you have been taking the antibiotic only in the evening and skipping the morning doses, it is advisable to consult your healthcare provider. They may recommend adjusting your treatment plan or provide guidance on how to proceed. It’s also important to complete the full course of antibiotics as prescribed, even if you start to feel better before finishing the medication. Stopping early can lead to a resurgence of the infection and contribute to antibiotic resistance.

In addition to the importance of adhering to the prescribed dosing schedule, it’s worth noting that antibiotics can have side effects. Common side effects include gastrointestinal issues such as nausea, diarrhea, and abdominal pain. If you experience severe side effects or signs of an allergic reaction (such as rash, itching, or difficulty breathing), seek medical attention immediately.

Lastly, if you have concerns about the effectiveness of the antibiotic due to missed doses or if you notice that your symptoms are not improving, it’s crucial to follow up with your healthcare provider. They can assess your condition and determine if a different treatment approach is necessary.

In summary, skipping doses of antibiotics can compromise their effectiveness and lead to complications such as antibiotic resistance. It’s essential to take medications as prescribed and communicate with your healthcare provider about any issues you encounter during your treatment.

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