Macular Degeneration: OCT vs. Fluorescein Angiography - Ophthalmology

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Macular degeneration


Hello, doctor.
Due to my high myopia, I have been regularly visiting the hospital for check-ups, including Optical Coherence Tomography (OCT) and dilated fundus examinations by the doctor.
Can dry or wet macular degeneration be detected through OCT, or is it necessary to perform fluorescein angiography? The doctor only mentioned that there are folds in the macula, but I am very concerned about the possibility of other macular conditions due to my poor eye health.
I kindly ask for your guidance.
Thank you.

AA, 60~69 year old female. Ask Date: 2022/04/09

Dr. He Jianxian reply Ophthalmology


Macular folds and age-related macular degeneration (AMD) are fundamentally different conditions.
The latter is classified into dry and wet forms, which can usually be distinguished through a fundus examination.
If that is not possible, Optical Coherence Tomography (OCT) can assist in diagnosis; however, fluorescein angiography is considered the most accurate method.
This information is provided for your reference.
Director He Jianxian, Department of Ophthalmology, Nantou Hospital.

Reply Date: 2022/04/09

More Info


Understanding macular degeneration, particularly in the context of high myopia, is crucial for maintaining eye health. Macular degeneration can be classified into two main types: dry (atrophic) and wet (neovascular). Both types can significantly impact vision, and early detection is key to managing these conditions effectively.

Optical Coherence Tomography (OCT) and fluorescein angiography are two important diagnostic tools used in the evaluation of macular degeneration. OCT is a non-invasive imaging technique that provides high-resolution cross-sectional images of the retina, allowing for detailed visualization of the retinal layers, including the macula. It is particularly useful in detecting changes in the retinal structure, such as thinning or thickening of the retinal layers, which can indicate the presence of dry macular degeneration. In cases of wet macular degeneration, OCT can reveal the presence of fluid, subretinal hemorrhage, or neovascularization.

On the other hand, fluorescein angiography is a procedure that involves injecting a fluorescent dye into the bloodstream and taking photographs of the retina as the dye circulates. This technique is particularly effective in identifying abnormal blood vessels associated with wet macular degeneration. It allows for the visualization of leakage, neovascularization, and other vascular changes that may not be apparent on OCT alone.

While OCT can provide valuable information about the structural changes in the retina, it may not always be sufficient for a comprehensive assessment of macular degeneration. For instance, in cases where there is a suspicion of wet macular degeneration, fluorescein angiography may be necessary to confirm the diagnosis and assess the extent of the disease. Therefore, both OCT and fluorescein angiography have their unique advantages and limitations, and they are often used in conjunction to provide a more complete picture of the patient's retinal health.

In your case, given your history of high myopia and the presence of yellow drusen or retinal changes, it is essential to continue regular monitoring and follow-up with your eye care provider. If your doctor has indicated that there are wrinkles in the macula, this could be a sign of early changes associated with macular degeneration. It is important to discuss any concerns you have regarding your vision, including any new symptoms such as distortion or blind spots, with your ophthalmologist.

Additionally, considering your high myopia, you are at an increased risk for various retinal complications, including macular degeneration. Regular eye examinations, including OCT and potentially fluorescein angiography, are critical in monitoring for any changes that could indicate the progression of macular degeneration or other retinal diseases.

In summary, both OCT and fluorescein angiography play vital roles in the diagnosis and management of macular degeneration. While OCT can detect structural changes in the retina, fluorescein angiography is essential for assessing vascular abnormalities, particularly in wet macular degeneration. It is advisable to maintain open communication with your eye care provider regarding your symptoms and the need for further testing to ensure timely intervention if necessary. Regular follow-ups and monitoring are key to preserving your vision and managing any potential complications associated with high myopia and macular degeneration.

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