Diabetes Management: Elevated Lab Values After Medication - Family Medicine

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Diabetes - After medication, the health check values increased in the red?


Hello Doctor, I was diagnosed with diabetes on January 5th this year.
Here are some key values for your reference: (January 5 report) HbA1c: 11.2% Fasting Glucose: 223 mg/dL Cholesterol: 209 mg/dL Total Bilirubin: 1.45 mg/dL (reference range 0.1-1.2) Direct Bilirubin: 0.42 mg/dL (reference range <0.3) Eosinophils: 2.2% (reference range 1-6) Urine Glucose: ++++ ==================================== (April 12 report - after three months of diabetes/hyperlipidemia medication) Fasting Glucose: 82 mg/dL Cholesterol: 146 mg/dL Total Bilirubin: 1.48 mg/dL (reference range 0.1-1.2) Direct Bilirubin: 0.55 mg/dL (reference range <0.3) Eosinophils: 6.6% (reference range 1-6) Urine Glucose: ++++ I would like to ask you, after taking medication for three months, along with dietary changes and light exercise, my blood sugar has significantly decreased, but I have some questions regarding certain values: 1.
Total Bilirubin and Direct Bilirubin were already elevated on January 5, and the clinic doctor mentioned it was not a concern.
However, the April 12 report shows an increase in these values again, and a referral was made for further examination.
Should I be concerned about this worsening? 2.
Eosinophils were at 2.2% (normal) on January 5, but jumped to 6.6% (elevated) on April 12.
What could be the cause of this? Does it pose any risk to my health? 3.
Urine Glucose was positive with four plus signs on both tests, but my blood sugar has decreased significantly.
What could be the reason for this? Can it be adjusted through dietary changes? Thank you very much for taking the time to review this.

Liao Xiaojie, 30~39 year old female. Ask Date: 2022/04/14

Dr. Hou Angting reply Family Medicine


Hello Ms.
Liao: It is recommended that you consult with a physician in the Family Medicine department for further advice and to arrange for examinations.
Wishing you good health.

Reply Date: 2022/04/14

More Info


Managing diabetes effectively requires a comprehensive understanding of various lab values and their implications for health. Based on the lab results you've provided, let's analyze your situation and address your concerns.


1. Total and Direct Bilirubin Levels
Your total bilirubin levels have shown a slight increase from 1.45 mg/dL to 1.48 mg/dL, while your direct bilirubin has risen from 0.42 mg/dL to 0.55 mg/dL. Elevated bilirubin levels can indicate issues with liver function or bile flow. While your doctor previously mentioned that these levels were not concerning, the increase warrants further investigation. Elevated bilirubin can be due to several factors, including liver disease, hemolysis (breakdown of red blood cells), or bile duct obstruction. It is essential to follow up with your healthcare provider for additional tests, such as liver function tests, to determine the underlying cause.


2. Eosinophil Count
Your eosinophil count increased from 2.2 (normal) to 6.6 (elevated). Eosinophils are a type of white blood cell involved in allergic reactions and parasitic infections. An elevated eosinophil count can indicate an allergic response, infection, or other inflammatory conditions. It is essential to discuss this change with your healthcare provider, as they may recommend further testing to identify the cause of the elevation. While an isolated increase in eosinophils may not pose an immediate risk, it could indicate an underlying condition that requires attention.


3. Urine Glucose Levels
The presence of glucose in your urine (urine glucose) is concerning, especially since it was positive on both occasions despite a significant decrease in blood glucose levels. Normally, glucose should not be present in urine unless blood glucose levels exceed the renal threshold (approximately 180 mg/dL). The fact that you are still testing positive for glucose in your urine suggests that your kidneys are excreting excess glucose, which can occur in poorly controlled diabetes.
To address this, it is crucial to continue managing your blood sugar levels through diet, exercise, and medication. While your blood glucose levels have improved, it may take time for your kidneys to adjust and for urine glucose levels to normalize. Additionally, consider discussing with your healthcare provider whether your current diabetes management plan is adequate or if adjustments are necessary.


Recommendations
1. Follow-Up Testing: Given the changes in your bilirubin and eosinophil levels, it is advisable to have follow-up tests to monitor these values and investigate any underlying issues.


2. Diabetes Management: Continue with your current diabetes management plan, focusing on maintaining a balanced diet, regular physical activity, and adherence to prescribed medications. Regular monitoring of your blood glucose levels is essential to ensure they remain within target ranges.

3. Communication with Healthcare Provider: Keep an open line of communication with your healthcare provider. Share your concerns regarding the lab results and any symptoms you may be experiencing. This will help them tailor your treatment plan to better suit your needs.

4. Lifestyle Modifications: Consider working with a dietitian or diabetes educator to optimize your dietary choices and exercise regimen. This can help improve your overall health and potentially reduce urine glucose levels.

In conclusion, while your blood glucose levels have improved significantly, the changes in bilirubin, eosinophils, and persistent urine glucose require further investigation and management. By staying proactive and engaged with your healthcare team, you can effectively manage your diabetes and address any emerging health concerns.

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