Persistent Mouth Sores: Could They Be Linked to Lymphoma? - Oncology

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The mouth ulcer has been persisting for quite a while without healing?


Hello doctor, last week I went to the hospital for an examination and found a small lump under my skin, measuring about 0.5 to 1.5 centimeters.
It doesn't hurt and doesn't move.
I consulted another physician here who suggested it might be folliculitis.
After visiting the hospital, the doctor examined it and said it probably isn't lymphadenopathy.
They also performed an ultrasound and confirmed it wasn't, but mentioned that the nearby lymph node is slightly swollen; however, the doctor reassured me that it was not a concern.
Recently, I developed a sore on one side of my mouth, so I started chewing on the other side, which then also became sore.
The first sore has healed, but the other one is still not better.
I visited a dentist who said it should heal in a day or two, but it has now been about five days and it hasn't improved.
Could this be related to the lymph nodes? I'm worried it might be lymphoma or something similar, as I've heard it can cause mouth sores.
I've read online that lymphoma can often be misdiagnosed, which is why I'm so concerned.
Here is the link to the photo of my sore: https://photos.google.com/share/AF1QipMedeu889mBfddpBWeeYHtxm7s-5FaJz9m8d9x_TEwuSROzqMyOFWR3iE0q3VucPA?key=MXB3aVNPZWgwa1Z5WmpiVENWV2swdUc1djN5VDRB.

Ju, 10~19 year old female. Ask Date: 2022/04/21

Dr. Chen Yunfang reply Oncology


Hello: I looked at the photos, and it doesn't appear to be cancer.
Please eat more fruits and vegetables, and wait a bit longer.
Additionally, if you have habits such as smoking, drinking alcohol, or chewing betel nut, please quit.
If there is no improvement in 2-3 weeks, please see a dentist or an ear, nose, and throat specialist.
Thank you.

Reply Date: 2022/04/21

More Info


Persistent mouth sores can be concerning, especially when there are accompanying symptoms or changes in your health. Based on your description, it seems you have been experiencing recurrent mouth sores, which have not healed as expected. You also mentioned a small lump that was evaluated and deemed not to be a swollen lymph node, but there is some mild lymphadenopathy noted.

Firstly, it's important to clarify that while persistent mouth sores can be associated with various conditions, including infections, autoimmune diseases, and even malignancies like lymphoma, the presence of mouth sores alone is not a definitive indicator of lymphoma. Lymphoma can sometimes present with oral manifestations, but these are typically accompanied by other systemic symptoms such as unexplained weight loss, night sweats, fever, or significant lymphadenopathy.

In your case, since the ultrasound indicated that the lump is not a swollen lymph node and the doctor assessed it as likely not concerning, this is reassuring. However, the persistent nature of your mouth sores is worth investigating further. Conditions that can cause recurrent mouth sores include:
1. Aphthous Stomatitis (Canker Sores): These are common and can be triggered by stress, certain foods, or nutritional deficiencies (like vitamin B12, folate, or iron).

2. Herpes Simplex Virus (HSV): This can cause recurrent sores, often in the form of cold sores, but can also affect the inside of the mouth.

3. Oral Thrush: A fungal infection that can cause white patches and soreness in the mouth.

4. Autoimmune Conditions: Conditions like Behçet's disease or lupus can lead to oral ulcers.

5. Lichen Planus: A chronic inflammatory condition that can cause painful sores in the mouth.

Given the duration of your symptoms (5 days without improvement), it would be prudent to follow up with your healthcare provider. They may consider additional evaluations, such as blood tests to check for nutritional deficiencies or autoimmune markers, or even a biopsy of the sore if it persists.
As for your concern about lymphoma, it is understandable to feel anxious, especially with the information available online. However, it is crucial to rely on clinical evaluations and diagnostic imaging rather than solely on internet research. If your healthcare provider has assessed the lymph nodes and the lump and found no cause for concern, it is likely that your symptoms are related to a more benign condition.

In summary, while persistent mouth sores can be linked to various conditions, including serious ones, your current evaluations suggest a lower likelihood of lymphoma. It is essential to continue monitoring your symptoms and maintain open communication with your healthcare provider. If the sores do not improve or worsen, or if you develop new symptoms, seeking further evaluation is warranted.

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