Do You Need Additional HPV Vaccines After Clearing Infections? - Obstetrics and Gynecology

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Dear Doctor: I was infected with HPV types 11, 16, and 18 in 2021.
I received the nine-valent vaccine in 2021 to protect against other types.
If I test in 2022 and find that the HPV types 11, 16, and 18 have cleared, do I need to receive the quadrivalent or nine-valent vaccine again to protect against the viruses I was previously infected with?

Lin Rui, 20~29 year old female. Ask Date: 2022/04/25

Dr. Wu Xianghui reply Obstetrics and Gynecology


There is no relevant research to prove that repeated administration of the same vaccine in a short period of time provides any substantial benefit.

Reply Date: 2022/04/25

More Info


When it comes to HPV (human papillomavirus) infections and vaccinations, understanding the nuances of immunity and vaccine efficacy is crucial. Your question about whether additional HPV vaccines are necessary after clearing infections, particularly for types 11, 16, and 18, is an important one.

Firstly, it's essential to clarify that the HPV vaccine is designed to prevent new infections from specific strains of the virus, rather than to treat existing infections. The nine-valent HPV vaccine (Gardasil 9) protects against nine types of HPV, including the high-risk types 16 and 18, which are associated with cervical cancer, and the low-risk types 6 and 11, which are linked to genital warts. If you were infected with HPV types 11, 16, and 18 and subsequently cleared these infections, the vaccine would not provide additional protection against those specific types since the vaccine does not eliminate existing infections.
However, if the virus types have cleared from your system, the vaccine can still provide protection against other HPV types that you have not been exposed to. This is particularly relevant if you received the vaccine after the infections were cleared, as it can help prevent future infections from other HPV types that you may encounter.

Regarding your question about whether you need to receive additional doses of the vaccine after clearing the infections, current medical guidelines suggest that there is no need for a booster dose of the HPV vaccine for individuals who have already completed the vaccination series. The immune response generated by the vaccine is generally long-lasting, and studies have shown that the vaccine continues to provide protection for many years after the initial series.
If you have already received the nine-valent vaccine, you do not need to receive the quadrivalent or any additional doses specifically for the types you were previously infected with, as the vaccine will not treat or prevent those infections. However, if you have concerns about your immunity or potential exposure to other HPV types, discussing this with your healthcare provider can provide personalized guidance based on your health history and risk factors.

In summary, if you have cleared HPV types 11, 16, and 18, there is no need for additional vaccinations specifically for those types. The nine-valent vaccine you received will continue to offer protection against other HPV types. Regular follow-ups with your healthcare provider are essential for monitoring your cervical health, especially after a history of HPV infection and treatment. It is also advisable to continue routine cervical cancer screenings as recommended, typically starting at age 21 and continuing based on your age and health history.

In conclusion, while the HPV vaccine is a powerful tool in preventing new infections, it does not treat existing infections. If you have cleared the virus, you are not at risk of transmitting it, and the vaccine will help protect you from other strains. Always consult with your healthcare provider for the most tailored advice regarding your health and vaccination status.

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