Urinary Hematuria: Causes and When to Seek Further Testing - Urology

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Urinary occult blood issue?


Hello Doctor, I had a urine test in early September last year that showed a trace of hematuria (1+) with red blood cells at 3-5, while all other parameters were normal.
Later, I underwent an intravenous pyelogram (IVP), and the doctor said everything was normal; the bladder, kidneys, and urinary tract were all fine, and there were no stones.
It was suggested that it might just be a phenomenon caused by microvascular rupture, and I shouldn't worry too much.
In October, I had another urine test, and there was no hematuria, with all other parameters normal.
In December, I tested urine again, but it seems that hematuria was not tested; however, the red blood cell count was normal (0-2), and all other parameters were also normal.

About two weeks ago, I tested urine again, and hematuria reappeared at 1+ (0.1), with red blood cells at 3-5, while all other parameters remained normal, and there was no protein in the urine.
I would like to ask the doctor: 1.
Is there a need for another IVP, or should I just continue to monitor? 2.
Are there other factors that could cause a hematuria reaction, such as holding urine, drinking insufficient water, or prolonged sample storage? Is that also a possibility? Thank you, Doctor, for taking the time to respond.

Chen, 30~39 year old female. Ask Date: 2022/05/10

Dr. Du Shixi reply Urology


Hello: 1.
Is there a need for another IVP, or is it sufficient to just observe? --> No need for another IVP unless there are symptoms, such as unilateral flank pain or visible hematuria.
2.
Are there other factors that can cause urine occult blood reactions? For example, holding urine, drinking too little water, or prolonged specimen storage? Could these also be possible? --> All of these are possible; vigorous exercise can also contribute.
As for prolonged specimen storage --> it should not be a significant factor.
Wishing you good health.

Reply Date: 2022/05/10

More Info


Urinary hematuria, or the presence of blood in urine, can be a concerning symptom that warrants further investigation. In your case, you have experienced intermittent episodes of hematuria, with previous tests showing normal results, including an intravenous pyelogram (IVP) that indicated no significant abnormalities. However, the recurrence of hematuria raises important questions regarding its underlying causes and the need for further testing.

1. Need for Further Imaging (IVP or Other Tests):
Given your history of hematuria and the recent positive test for urinary blood, it is reasonable to consider whether further imaging is necessary. While your previous IVP was normal, the recurrence of hematuria suggests that there may be an underlying issue that needs to be addressed. Factors such as urinary tract infections, kidney stones, or even benign conditions like microvascular bleeding can contribute to hematuria. If the hematuria persists or is accompanied by other symptoms (such as pain, changes in urination, or systemic symptoms), further imaging studies, such as a CT scan or repeat IVP, may be warranted to rule out any structural abnormalities or lesions in the urinary tract.

2. Other Factors Contributing to Urinary Hematuria:
There are several non-pathological factors that can lead to transient hematuria. For instance, dehydration or concentrated urine can sometimes cause irritation of the urinary tract, leading to blood in the urine. Additionally, activities such as vigorous exercise or trauma to the urinary tract can also result in hematuria. Holding urine for extended periods or not drinking enough fluids may exacerbate these conditions.
Furthermore, certain medications, dietary factors (like beet consumption), or even menstrual blood contamination can lead to false-positive results for hematuria. It is essential to ensure that the urine sample is collected properly, ideally midstream, to minimize contamination from the genital area.
3. Monitoring and Follow-Up:
Since your hematuria has been intermittent and other urine parameters have remained normal, it may be appropriate to monitor the situation closely. Keeping a log of any associated symptoms, dietary habits, and fluid intake can provide valuable information for your healthcare provider. If the hematuria persists or worsens, or if you develop new symptoms, seeking further evaluation would be prudent.

4. Consultation with a Specialist:
If you have not already done so, consider consulting a urologist. They can provide a more comprehensive evaluation and may recommend additional tests, such as a cystoscopy, to directly visualize the bladder and urethra. This can help identify any potential sources of bleeding that may not be visible on imaging studies.

In summary, while your previous tests have been reassuring, the recurrence of hematuria should not be ignored. It is essential to maintain open communication with your healthcare provider, consider further testing if symptoms persist, and explore all potential contributing factors. Regular follow-ups and monitoring will help ensure that any underlying issues are addressed promptly, thereby safeguarding your urinary health.

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