Amoxicillin Use for Dental Procedures in Heart Patients - Dentistry

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Medication Consultation: Amoxicillin


Hello Doctor, I currently have mitral valve prolapse with mild mitral regurgitation.
My doctor informed me that I need to take antibiotics before dental procedures to prevent endocarditis.
Recently, after undergoing a root canal treatment, my doctor prescribed me 500 mg of Amoxicillin, to be taken four times a day for three days, and mentioned that I could take more if needed.
I would like to ask if prophylactic antibiotics like this should be taken beforehand? Also, is it necessary to complete the three-day course? After taking the antibiotics, I experienced increased heart rate, fatigue, and cloudy urine, and I don't feel very well.
Thank you for your assistance!

Awei, 20~29 year old female. Ask Date: 2022/05/22

Dr. Lin Jiayong reply Dentistry


Hello: The preoperative antibiotic is a single dose of 2g of Amoxicillin.
If taken postoperatively, it is recommended to complete the entire course.
If you are allergic to Amoxicillin or experience adverse reactions, consider switching to another broad-spectrum antibiotic.
It is advisable to confirm with your cardiologist which antibiotic is suitable for you.
Sincerely, Lin Chia-Yung, Dental Department, Taichung Hospital, Ministry of Health and Welfare.

Reply Date: 2022/05/22

More Info


When it comes to the use of Amoxicillin as a prophylactic antibiotic for patients with mitral valve prolapse (MVP) and mild mitral regurgitation (MR), it is essential to understand both the rationale behind its use and the potential side effects that can arise from its administration.

For patients with certain heart conditions, including MVP with regurgitation, there is a risk of infective endocarditis, which is an infection of the inner lining of the heart. This risk is particularly heightened during dental procedures, where bacteria from the mouth can enter the bloodstream. To mitigate this risk, the American Heart Association recommends prophylactic antibiotics, such as Amoxicillin, prior to dental procedures that are likely to cause bleeding.

In your case, the prescription of 500 mg of Amoxicillin taken four times a day for three days is a common regimen for preventing infective endocarditis. However, it is crucial to take the antibiotic before the dental procedure rather than after. The standard practice is to administer the antibiotic one hour before the procedure to ensure adequate levels in the bloodstream during the time bacteria may enter the bloodstream.

Regarding your concerns about whether you should finish the three-day course of antibiotics: if the antibiotic was prescribed after the dental procedure, it is generally advisable to complete the course as directed by your healthcare provider. This is to ensure that any potential infection is adequately treated, even if it was not the primary reason for the prescription.

You mentioned experiencing side effects such as increased heart rate, fatigue, and cloudy urine after taking Amoxicillin. While Amoxicillin is generally well-tolerated, some individuals may experience side effects, including gastrointestinal disturbances, allergic reactions, or changes in urine color. Increased heart rate and fatigue could also be related to anxiety or stress regarding your health condition rather than the antibiotic itself. However, if these symptoms persist or worsen, it is essential to consult your healthcare provider. They may consider adjusting your treatment plan or exploring alternative antibiotics if you are experiencing adverse effects.

In summary, for patients like yourself with MVP and mild MR, taking Amoxicillin as a prophylactic measure before dental procedures is crucial to prevent infective endocarditis. It is best to take the antibiotic before the procedure and to complete the prescribed course if it was intended for post-procedure prophylaxis. If you experience significant side effects, do not hesitate to reach out to your healthcare provider for further evaluation and guidance. Your health and comfort are paramount, and your healthcare team is there to support you through this process.

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