Autonomic Nervous System Disorders and Functional Gastrointestinal Issues - Psychiatry

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Autonomic Nervous System Dysregulation vs. Functional Gastrointestinal Disorders?


I have been diagnosed by a physician with functional gastrointestinal disorders caused by autonomic nervous system dysfunction.
I have been prescribed the following three medications, and I would like to understand their effects and side effects.
Thank you! (The following are the dosages for a single administration): Foan 10mg, Homagyl 50mg, Diazepam 2mg.
I have heard that there are addiction side effects; how long does it take for addiction to develop? Currently, I take these medications once a day.
Could these medications cause indigestion or abnormal gastrointestinal motility? (I mostly do not feel hungry and experience bloating with no appetite.) Thank you!
(1) I still have issues with gastrointestinal indigestion and have consulted a gastroenterologist.
The doctor prescribed me the following medications; can I take them together with Foan 10mg, Homagyl 50mg, and Diazepam 2mg? Simethicone (Kascoal) 40mg after each meal, once; Primperan 5mg before each meal, once; Famotidine (Gaster) 20mg once before bed; Strocain after each meal, once.
(2) How should I seek further consultation? (Neurology? Gastroenterology?)
(3) Is gastrointestinal indigestion due to slow gastrointestinal motility? Are there any physical methods to improve this? (Such as abdominal massage, applying medicated oil, etc.)
(4) Since I take Foan, Homagyl, and Diazepam only once a day, should I gradually reduce the dosage as my condition improves (initially three times a day)? Thank you.

Johnson Jin, 30~39 year old female. Ask Date: 2003/08/20

Dr. Chen Wenke reply Psychiatry


Hello Johnson:
In response to your previous two emails regarding your current condition, I would like to address your questions.
There is no significant evidence of gastric ulcers.
It is clear that many of your gastrointestinal discomfort symptoms are closely related to autonomic nervous system dysregulation and stress.
Therefore, the medication you are taking, diazepam 2mg, is not a high dose.
Its primary function is to relax the smooth muscles of the stomach, alleviating discomfort caused by anxiety and stress.
Some physicians may prescribe a dosage of three times a day, which has shown good results.
The current dosage you are using is not considered high, and if this dosage helps you maintain stability, there is no need to worry about further reduction.
As for the timing of your medication, you can adjust it according to your daily schedule; taking it before bedtime should be fine.
Regarding kascoal, primperan, garter, and strocain, these are all medications related to gastrointestinal issues, primarily aimed at addressing bloating and poor digestion.
Foam 10mg contains oxazepam, which is an anti-anxiety medication, and its mechanism and purpose are similar to those of diazepam.
Additionally, concerning the medications, both diazepam and foam are classified as Schedule IV controlled substances, which have the potential for dependence.
Therefore, caution is advised in their use.
Based on what you have described, it does not seem that you are in a state of dependence, so there is no need for excessive concern.

Reply Date: 2003/08/20

More Info


Understanding autonomic nervous system (ANS) disorders and functional gastrointestinal (GI) issues is crucial for managing symptoms effectively. Your situation, characterized by autonomic dysfunction leading to functional gastrointestinal disorders, is not uncommon. The medications prescribed to you—Foan (10mg), Homagyl (50mg), and Diazepam (2mg)—each serve specific purposes, and understanding their effects and potential side effects is essential for your treatment plan.


1. Medication Overview
Foan (10mg): This medication contains oxazepam, which is an anxiolytic that helps reduce anxiety and can also have a muscle relaxant effect. It is often used to alleviate symptoms related to anxiety, which can exacerbate gastrointestinal issues. Common side effects include drowsiness, dizziness, and potential dependency with prolonged use. The risk of addiction increases with higher doses and longer duration of use, typically after several weeks of continuous use.

Homagyl (50mg): This medication contains homatropine, which is an anticholinergic agent. It works by reducing gastrointestinal motility, which can help alleviate cramping and spasms in the gut. However, it may also lead to side effects such as dry mouth, constipation, and blurred vision. Its effect on gut motility can sometimes contribute to feelings of bloating or fullness, especially if the gut is already sluggish.

Diazepam (2mg): This is another anxiolytic that can help with anxiety and muscle relaxation. Similar to Foan, it carries a risk of dependency, especially if taken regularly over an extended period. Side effects may include sedation, dizziness, and impaired coordination. It is crucial to avoid alcohol while taking this medication, as it can enhance sedative effects.


2. Potential for Addiction
Regarding the concern about addiction, it is generally understood that benzodiazepines (like Diazepam) and other anxiolytics can lead to dependency if used continuously for several weeks or longer. The timeline for developing a dependency varies among individuals, influenced by factors such as dosage, duration of use, and personal history of substance use. It is advisable to follow your physician's guidance on the duration of use and to have regular check-ins about your medication regimen.


3. Gastrointestinal Effects
The medications you are taking can influence gastrointestinal motility. Diazepam and Foan may slow down gut motility, which could contribute to feelings of bloating and decreased appetite. If you are experiencing persistent gastrointestinal discomfort, it is essential to discuss this with your healthcare provider, as they may need to adjust your medications or explore other treatment options.


4. Combining Medications
You mentioned additional medications such as Simethicone (Kascoal), Primperan, Famotidine (Gaster), and Strocain. Generally, these medications can be combined with your current regimen, but it is crucial to consult your healthcare provider before doing so. Simethicone helps relieve gas and bloating, Primperan (metoclopramide) enhances gastric emptying, and Famotidine reduces stomach acid, which may help with your symptoms. Always ensure that your healthcare provider is aware of all medications you are taking to avoid potential interactions.


5. Seeking Further Help
For ongoing gastrointestinal issues, it may be beneficial to consult both a gastroenterologist and a neurologist, as your symptoms may require a multidisciplinary approach. The gastroenterologist can address the functional aspects of your GI symptoms, while the neurologist can provide insights into the autonomic nervous system's role in your condition.


6. Improving Gastrointestinal Motility
To improve gastrointestinal motility, consider non-pharmacological approaches such as:
- Dietary Changes: A high-fiber diet can promote regular bowel movements. Staying hydrated is also essential.

- Physical Activity: Regular exercise can stimulate gut motility and improve overall digestive health.

- Massage: Abdominal massage may help relieve bloating and promote movement in the intestines.

- Stress Management: Techniques such as yoga, meditation, and deep-breathing exercises can help manage stress, which may improve autonomic function and GI symptoms.


Conclusion
In summary, your medications serve specific purposes in managing anxiety and gastrointestinal symptoms, but they also come with potential side effects and risks of dependency. It is essential to maintain open communication with your healthcare provider regarding your treatment plan and any ongoing symptoms. By combining medication with lifestyle changes and stress management techniques, you can work towards improving your overall health and well-being.

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