Considering IVF After Multiple Failed Pregnancies: Your Questions Answered - Obstetrics and Gynecology

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I want to get pregnant?


Hello Dr.
Jan: I am a loyal reader of yours and would like to ask you some questions.
I have undergone four cycles of artificial insemination; I became pregnant during the first cycle but unfortunately miscarried at six weeks.
The subsequent attempts have all failed.
Should I consider in vitro fertilization (IVF)? I currently lack confidence in myself and my doctor, and I really don’t know what to do.
Despite undergoing multiple tests, no cause has been identified.
Recently, my doctor informed me that my prolactin levels are elevated, and I need to take medication until I become pregnant.
However, due to the SARS situation, I haven’t taken the medication, and my levels remain high.
What is the threshold for prolactin levels that is considered concerning, and could this be a significant factor affecting my ability to conceive? Is the white discharge I am experiencing a remnant from pregnancy? Thank you for your hard work and for addressing my concerns.

shelly, 30~39 year old female. Ask Date: 2003/08/20

Dr. Zhan Deqin reply Obstetrics and Gynecology


Elevated prolactin levels can be caused by various factors, such as pituitary tumors, pregnancy, or the use of certain sedatives and gastrointestinal medications.
If prolactin levels remain excessively high, it may lead to difficulties in conceiving.
Generally, levels above 30 ng/mL are considered elevated.
Currently, the success rate for in vitro fertilization (IVF) in the country is approximately over 30%, so it may be worth trying.

Reply Date: 2003/08/20

More Info


When considering the transition from multiple failed pregnancies to in vitro fertilization (IVF), it's essential to understand the various factors that can influence your fertility journey. Your experience of having undergone four artificial insemination attempts, with one resulting in a miscarriage at six weeks, can understandably lead to feelings of frustration and uncertainty. Let's explore your concerns and the potential next steps.

Firstly, it's important to recognize that recurrent pregnancy loss can be multifactorial. While you mentioned that extensive testing has not revealed any clear reasons for your difficulties, there are several common factors that can contribute to repeated failures, including hormonal imbalances, anatomical issues, genetic factors, and even immunological responses. The elevated prolactin levels you mentioned could indeed play a role in your fertility. Prolactin is a hormone produced by the pituitary gland, and elevated levels can interfere with ovulation and menstrual cycles, making conception more challenging. Typically, a prolactin level above 25 ng/mL is considered elevated, but the threshold can vary based on individual circumstances and laboratory standards. It is crucial to address this hormonal imbalance, as normalizing prolactin levels can improve your chances of conception.

Regarding your question about the white discharge you are experiencing, it is possible that this could be related to hormonal changes or remnants from previous pregnancies. However, it is essential to discuss these symptoms with your healthcare provider to rule out any underlying conditions, such as infections or hormonal imbalances.

As for the consideration of IVF, it can be a viable option for couples who have faced multiple unsuccessful attempts at conception through less invasive methods. IVF allows for a more controlled environment where eggs and sperm can be combined, and embryos can be monitored for quality before implantation. This method can also bypass certain anatomical issues, such as blocked fallopian tubes, which you may have experienced in the past.
If you are feeling uncertain about your current treatment plan or the effectiveness of your healthcare provider, it may be beneficial to seek a second opinion from a fertility specialist. They can provide a fresh perspective on your situation and may suggest additional testing or treatment options that have not yet been considered.

In terms of improving your chances of success with IVF, several strategies can be employed. These include optimizing your overall health through a balanced diet, regular exercise, and maintaining a healthy weight. Additionally, managing stress through mindfulness practices or counseling can also be beneficial, as stress can negatively impact fertility.

Lastly, it is essential to maintain open communication with your healthcare provider. Discuss your concerns, ask questions about the IVF process, and express any feelings of doubt or anxiety you may have. A supportive and understanding healthcare team can make a significant difference in your fertility journey.

In summary, while the path to conception can be fraught with challenges, there are options available, including IVF, that may help you achieve your goal of pregnancy. Addressing hormonal imbalances, seeking additional medical opinions, and maintaining a healthy lifestyle can all contribute to improving your chances of success. Remember, you are not alone in this journey, and many resources and support systems are available to help you navigate the complexities of fertility treatment.

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