Noninvasive Follicular Thyroid Neoplasm: What You Need to Know - Surgery

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Thyroid issues?


The report states: Dx: Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features.
MICRO D: papillary thyroid carcinoma arranged in a follicular pattern.
Thank you, Dr.
Chen, for your previous response.
I instinctively associate carcinoma with malignancy, but my doctor reviewed the diagnosis and directly informed me that it is benign and non-malignant, so there is no further treatment.
This has left me a bit worried.

aei, 30~39 year old female. Ask Date: 2022/05/26

Dr. Chen Bingze reply Surgery


Hello, I apologize.
I just asked the pathologist, and they have currently reclassified this type of tumor as benign, so your doctor is correct.
(Research has indicated that the prognosis for this type of tumor is very good, which is why it has been changed from malignant to benign.)

Reply Date: 2022/05/26

More Info


Understanding Noninvasive Follicular Thyroid Neoplasm (NFTN) is crucial for patients who have undergone thyroid surgery and received pathology reports that may seem confusing. In your case, the report indicates "Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features" and mentions "papillary thyroid carcinoma arranged in follicular pattern." This combination of terms can indeed lead to uncertainty regarding the nature of the tumor—whether it is benign or malignant.

To clarify, "Noninvasive Follicular Thyroid Neoplasm" is classified as a type of thyroid tumor that does not invade surrounding tissues. This is a relatively new classification that has emerged from the evolving understanding of thyroid neoplasms. The term "noninvasive" suggests that the tumor is not spreading beyond its capsule, which is a characteristic of benign tumors. However, the presence of "papillary thyroid carcinoma" in the report complicates the interpretation.

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer and is generally associated with a good prognosis. When the report mentions "papillary thyroid carcinoma," it indicates that there are features typical of malignancy present in the tumor. However, the key distinction here is that the tumor is described as "noninvasive." This means that while it has characteristics of a carcinoma, it has not invaded surrounding tissues, which is a critical factor in determining the aggressiveness of the disease.

In recent years, the classification of thyroid tumors has become more nuanced. The World Health Organization (WHO) has recognized noninvasive follicular thyroid neoplasm with papillary-like nuclear features as a distinct entity. This classification is significant because it helps to identify tumors that may have malignant features but do not exhibit invasive behavior, thus potentially sparing patients from unnecessary aggressive treatments.

Your physician's interpretation of the report as indicating a benign condition is consistent with current guidelines, which suggest that noninvasive follicular thyroid neoplasms with papillary-like nuclear features typically do not require aggressive treatment or follow-up, unlike invasive papillary thyroid carcinoma. However, it is essential to maintain regular follow-ups and monitoring, as with any thyroid condition, to ensure that there are no changes in the tumor's behavior.

In summary, while the presence of "carcinoma" in the report may initially raise concerns, the classification of "noninvasive" indicates that the tumor is not currently exhibiting malignant behavior. It is advisable to have open discussions with your healthcare provider about your specific case, including any concerns you may have regarding follow-up care and monitoring. Understanding the nuances of thyroid pathology can be complex, but with the right information and support, you can navigate your health decisions more confidently.

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