High WBC and Ketone Levels: What Your Test Results Mean - Family Medicine

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Ketones and elevated white blood cell (WBC) count?


Hello Doctor, here are the results from my blood and urine tests conducted yesterday:
- WBC esterase: Trace
- Ketone: 4+ (160)
- Protein: Trace (15)
- Segment: 76
- Creatinine: 0.53
- Lymphocyte: 17.9
- Eosinophil: 0.6
- Basophil: 0.6
- WBC: 11.3
- RBC: 33.5
- Platelets: 257
- MCV: 84.4
- MCHC: 33.5
- MCH: 28.3
- Hematocrit: 40.6
- Hemoglobin: 13.6
I visited my family physician due to abdominal pain during ovulation and mild tenderness in the lower right abdomen without rebound tenderness.
The doctor assessed that there were no acute issues, but blood tests were conducted to check for hyperthyroidism.
I had a sandwich at 6 AM and did not eat again until around 14:30 when the tests were conducted.
Currently, I am experiencing mild diarrhea.
I would like to ask the doctor about the significance of the few values that are highlighted in red.

Lin, 20~29 year old female. Ask Date: 2022/05/27

Dr. Lin Zhebin reply Family Medicine


Hello: An elevated white blood cell count typically indicates an infection or inflammation in the body.
Given your symptoms of abdominal pain and diarrhea, there may be a concern for gastrointestinal infection or inflammation, as well as potential issues with other intra-abdominal organs.
However, it is particularly important to note your symptom of right lower abdominal pain, which raises the concern for appendicitis.
Additionally, the presence of elevated ketones in your urine may be related to fasting prior to blood tests.
It is also important to monitor for any blood sugar issues; if both urine glucose and fasting blood glucose levels are normal, there is no need for excessive concern.
In summary, if you do not experience any significant discomfort, you should follow up with your original physician at the scheduled time.
If your abdominal pain and diarrhea worsen, or if you experience fever and vomiting, it is advisable to seek medical attention immediately.

Reply Date: 2022/05/27

More Info


Understanding your test results, particularly the elevated white blood cell (WBC) count and the presence of ketones, is crucial for assessing your health status. Let's break down the findings and their potential implications.


Elevated WBC Count
Your WBC count is reported at 11.3, which is slightly above the normal range (typically 4.5 to 11.0 x 10^9/L). An elevated WBC count can indicate several conditions, primarily related to the body's response to infection or inflammation. Given your symptoms of abdominal pain and diarrhea, this elevation may suggest an underlying infection, possibly gastrointestinal in nature.
1. Infection or Inflammation: The presence of abdominal pain, especially in the right lower quadrant, raises concerns for conditions such as appendicitis or other gastrointestinal infections. The WBC count can rise as the body fights off these infections.


2. Stress Response: Physical stress, such as fasting or significant discomfort, can also lead to a temporary increase in WBC count. Since you fasted from 6 AM until your test at 2:30 PM, this could have contributed to the elevation.

3. Other Causes: Conditions such as allergies, autoimmune diseases, or even certain medications can also elevate WBC counts. However, given your acute symptoms, an infectious process is more likely.


Presence of Ketones
The ketone level in your urine is reported as 4+, which is significantly elevated. Ketones are produced when the body breaks down fat for energy instead of carbohydrates, often occurring in states of fasting, prolonged exercise, or uncontrolled diabetes.

1. Fasting State: Since you did not eat from 6 AM until your test, your body may have entered a state of ketosis, leading to elevated ketone levels. This is particularly common if carbohydrate intake is low, as the body shifts to fat metabolism.

2. Diabetes Consideration: If you have a history of diabetes or symptoms suggestive of high blood sugar (such as increased thirst, frequent urination, or fatigue), it is essential to check your blood glucose levels. High ketone levels can indicate that your body is not utilizing glucose effectively, which can be dangerous if you have diabetes.

3. Gastrointestinal Issues: Diarrhea can lead to dehydration and electrolyte imbalances, which may also contribute to ketosis. If your diarrhea persists, it is crucial to maintain hydration and consider dietary adjustments.


Summary and Recommendations
Given your test results and symptoms, it is advisable to monitor your condition closely. Here are some recommendations:
- Follow-Up with Your Doctor: Since you have abdominal pain and diarrhea, it is essential to follow up with your healthcare provider, especially if your symptoms worsen or do not improve. They may recommend further tests, such as imaging studies or stool tests, to rule out infections or other gastrointestinal issues.

- Hydration: Ensure you are adequately hydrated, especially if you are experiencing diarrhea. Consider oral rehydration solutions to replenish lost fluids and electrolytes.

- Dietary Considerations: If you are fasting or have dietary restrictions, it may be beneficial to discuss a balanced diet with your healthcare provider to prevent ketosis and maintain overall health.

- Monitor Symptoms: Keep track of any new symptoms, such as fever, worsening abdominal pain, or changes in bowel habits, and report these to your doctor promptly.

In conclusion, while your elevated WBC count and ketone levels warrant attention, they can often be explained by your recent fasting and current gastrointestinal symptoms. However, close monitoring and follow-up with your healthcare provider are essential to ensure your health and address any underlying issues.

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