Drug Side Effects: Breast Pain from Endometriosis Treatment - Breast and Thyroid

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Hello doctor, I have endometriosis and have been taking medication for it.
Recently, I noticed tenderness on the inner lower edge of my breast when pressed, but it doesn't hurt when I'm not touching it.
I would like to know if this could be a side effect of the medication.
Thank you for your response.

Joi, 30~39 year old female. Ask Date: 2022/06/07

Dr. Yuan Tianmin reply Breast and Thyroid


This medication may slightly affect your menstrual cycle and could also lead to breast tenderness.
If you are concerned, you can consider getting a breast ultrasound for further evaluation.

Reply Date: 2022/06/07

More Info


Breast pain, or mastalgia, can be a concerning side effect for individuals undergoing treatment for endometriosis, particularly when using medications like dienogest (often referred to as "Dostinex" in some contexts, although this is primarily used for hyperprolactinemia). It's important to understand that hormonal treatments for endometriosis can influence breast tissue due to their effects on estrogen and progesterone levels.

Dienogest is a synthetic progestin that is commonly used in the management of endometriosis. It works by suppressing the growth of endometrial tissue and reducing the associated pain. However, one of the known side effects of progestins is breast tenderness or pain. This occurs because these medications can stimulate breast tissue, leading to discomfort. The pain you are experiencing, particularly localized to the inner and lower areas of the breast, could indeed be related to the use of dienogest.
When considering whether this breast pain is a side effect of your medication, it is essential to evaluate the timing and nature of the pain. If the discomfort began after starting the medication and is consistent with the known side effects, it is plausible that the drug is contributing to your symptoms. However, it is also important to rule out other potential causes of breast pain, such as fibrocystic changes, cysts, or other breast conditions, which can also present with localized pain.

Given your situation, it is advisable to consult with your healthcare provider. They may recommend a breast ultrasound or mammogram to ensure that there are no underlying issues that need to be addressed. If the imaging studies are normal and the pain is indeed attributed to the medication, your doctor might consider adjusting your treatment plan. This could involve switching to a different medication or modifying the dosage to alleviate the side effects while still effectively managing your endometriosis.

In addition to medication adjustments, there are other strategies to manage breast pain. These can include lifestyle modifications such as wearing a supportive bra, reducing caffeine intake, and using over-the-counter pain relief options like NSAIDs (non-steroidal anti-inflammatory drugs) if appropriate.
It's also worth noting that while breast pain can be a common side effect of hormonal treatments, it is usually temporary and may resolve as your body adjusts to the medication. However, persistent or severe pain should always be evaluated by a healthcare professional to rule out any serious conditions.

In summary, the breast pain you are experiencing could be a side effect of the dienogest treatment for endometriosis. It is crucial to discuss this with your healthcare provider, who can help determine the best course of action, including potential imaging studies and treatment adjustments. Your health and comfort are paramount, and addressing side effects is an essential part of managing any chronic condition.

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