Aspirin's Impact on Menstrual Cycle and Ovulation

Aspirin can cause an increase in body temperature?

Hello, doctor.
I have been experiencing irregular menstrual cycles for many years.
In preparation for pregnancy, I have been taking ovulation medication for three consecutive months.
After starting the medication, my menstrual cycle has been consistently 30 days, with a biphasic temperature pattern lasting 14-16 days, ranging from 36.75-37.05°C and 36.30-36.65°C, respectively.
In the second month (last month), on the 12th day of my cycle, my doctor noted that my endometrium was thinner due to the medication, so he prescribed aspirin and Chuanxiong Chaotong tablets for 15 days.
By the 17th day of my cycle, the endometrial thickness increased to 13 mm.
I continued taking the medication, and the high temperature persisted until the 3rd day of my menstrual cycle in the third month.
On the same day, my doctor prescribed ovulation medication for 5 days, along with aspirin and Chuanxiong for 28 days.
After taking them, my body temperature dropped for two days and then began to rise again (as follows).
I sleep with the air conditioning on for 7 hours each night and measure my temperature upon waking.
The night before my temperature began to rise, I experienced a recurrence of a previous gastric issue, with persistent burping and stomach discomfort.
I would like to ask what might be causing my temperature fluctuations and whether it could affect ovulation.
Also, will taking aspirin for 28 days cause the endometrium to become too thick?
Here are my temperatures for the first three days of my third menstrual cycle:
Day 1: 36.85°C
Day 2: 36.76°C
Day 3: 36.79°C (started taking ovulation medication, aspirin, and Chuanxiong)
Day 4: 36.66°C
Day 5: 36.63°C
Day 6: 36.79°C (menstruation ended; stomach discomfort began the night before)
Day 7: 36.86°C (stomach discomfort)
Day 8: 36.87°C (stomach discomfort)

Jean, 30~39 year old female. Ask Date: 2022/06/14

Dr. Cao Guotao reply Obstetrics and Gynecology

Hello, aspirin does not affect high temperatures or ovulation.
Please follow your obstetrician's instructions.
Wishing you good health.

Reply Date: 2022/06/14

More Info

Aspirin, known for its anti-inflammatory and antiplatelet properties, is often used in various medical contexts, including cardiovascular health and pain relief. However, its impact on the menstrual cycle and ovulation is a nuanced topic that requires careful consideration, especially for individuals trying to conceive.

Firstly, it is important to understand how aspirin may interact with the menstrual cycle. Some studies suggest that low-dose aspirin can improve uterine blood flow, which may positively influence the endometrial lining. A thicker endometrial lining is generally favorable for implantation and can enhance the chances of conception. In your case, the administration of aspirin led to an increase in endometrial thickness, which is a positive sign for fertility.

Regarding ovulation, aspirin does not directly induce ovulation but may have an indirect effect by improving blood flow to the reproductive organs. This improved circulation can enhance the overall health of the ovaries and the endometrium, potentially creating a more conducive environment for ovulation and implantation. However, it is crucial to monitor how your body responds to the medication, especially since you have a history of gastrointestinal issues.

Your observation of fluctuating basal body temperatures (BBT) is also noteworthy. BBT can be influenced by various factors, including hormonal changes, medication, and even environmental conditions such as sleeping in a cold room. The rise in temperature typically indicates ovulation, while a drop may suggest the onset of menstruation. The fact that your temperatures are fluctuating could be attributed to the hormonal effects of the ovulation medications you are taking, as well as the aspirin.
As for your concern about aspirin causing the endometrium to become too thick, it is generally not a concern with low-dose aspirin. In fact, the goal is often to maintain a healthy balance where the endometrium is adequately thick for implantation but not excessively so, which could lead to complications. Continuous monitoring by your healthcare provider is essential to ensure that your endometrial health is optimal.

The gastrointestinal discomfort you are experiencing could be a side effect of aspirin, as it can irritate the stomach lining, particularly in individuals with a history of gastric issues. It is advisable to take aspirin with food or to discuss with your doctor the possibility of using a buffered formulation to minimize gastrointestinal side effects.

In summary, while aspirin can have beneficial effects on the menstrual cycle and may support fertility by improving endometrial thickness, it is essential to monitor your body's responses closely. Your healthcare provider should be your primary resource for managing your medications and any side effects you experience. If you notice significant changes in your menstrual cycle, ovulation patterns, or gastrointestinal health, it is crucial to communicate these changes to your doctor for further evaluation and guidance.

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