Can You Take Lonfadroxil Antibiotics While on Oral A Acid?

Oral isotretinoin and antibiotics?

I am currently taking oral isotretinoin.
Since I didn't have a consultation on the weekend, I visited another clinic where they prescribed me Lonfadroxil Capsules 500 mg.
Is it safe for me to take Lonfadroxil Capsules 500 mg while on isotretinoin?

jiwei, 30~39 year old female. Ask Date: 2022/06/25

Dr. Wu Yuxin reply Dermatology

Not recommended.

Reply Date: 2022/06/25

More Info

When considering the concurrent use of Lonfadroxil (an antibiotic) and oral isotretinoin (commonly referred to as A acid), it is crucial to understand the potential interactions and safety concerns associated with this combination. Isotretinoin is a powerful medication primarily used to treat severe acne, and it has a well-documented profile of side effects, including potential impacts on liver function, lipid levels, and skin sensitivity.

Firstly, it is generally advised to avoid combining isotretinoin with certain medications, particularly those that can affect liver function or increase the risk of side effects. While Lonfadroxil is not specifically known to have severe interactions with isotretinoin, the combination of any antibiotic with isotretinoin should be approached with caution. The primary concern is the potential for increased strain on the liver, as both medications can influence liver enzymes. Isotretinoin can elevate liver enzymes and affect lipid metabolism, and antibiotics can also have varying effects on liver function depending on the specific drug and the individual's health status.

Moreover, isotretinoin is known to cause dryness and sensitivity in the skin and mucous membranes, which can be exacerbated by certain antibiotics. If Lonfadroxil causes gastrointestinal upset or other side effects, it may complicate the management of isotretinoin's side effects, such as dryness or irritation.

In addition to the pharmacological interactions, it is essential to consider the underlying reason for the antibiotic prescription. If the antibiotic is being prescribed for an infection that is not related to the skin condition being treated with isotretinoin, it may be necessary to evaluate the need for the antibiotic in the context of the overall treatment plan.
It is also worth noting that isotretinoin is typically prescribed with strict monitoring due to its potential side effects, including teratogenicity (causing birth defects) and the need for regular blood tests to monitor liver function and lipid levels. Therefore, any additional medications, including antibiotics, should be discussed with the prescribing physician to ensure that they do not interfere with the isotretinoin treatment or exacerbate any side effects.

In conclusion, while there may not be a direct contraindication to taking Lonfadroxil while on isotretinoin, it is not generally recommended without the guidance of a healthcare professional. It is crucial to consult with your dermatologist or healthcare provider to discuss your specific situation, including the reasons for taking both medications, any potential side effects, and the best course of action for your treatment plan. They can provide personalized advice based on your medical history and current health status, ensuring that you receive safe and effective care.

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