Can Women with IgA Nephropathy Safely Get Pregnant?

Can a person with IgA nephropathy become pregnant and give birth?

Hello, doctor.
I was diagnosed with IgA nephropathy and minimal change disease after undergoing a kidney biopsy in the past.
My condition is currently stable, with no proteinuria or hematuria, and my kidney function is normal.
I have recently stopped taking steroids but continue to take a medication that helps with circulation (Pentoxifylline).
When I first became ill, a family member who is a nurse advised me against getting pregnant, as it could put a significant strain on my kidneys.
Therefore, I would like to understand if I have a chance of becoming pregnant and having children in the future given my current situation.
Additionally, I would like to ask if patients like me typically need to take these medications for life.
Thank you, doctor!

Niming, 20~29 year old female. Ask Date: 2022/06/28

Dr. Wu Jiyu reply Internal Medicine

Based on the information provided in the literature, if blood pressure is normal and the glomerular filtration rate is greater than 70 ml/min, the impact of pregnancy on the kidneys can be minimized.
However, it is essential to discuss your specific situation with your attending physician regarding whether long-term medication is necessary, as this will depend on your medical condition.
Thank you for your inquiry.
The Nephrology Department at Changhua Hospital cares about you.

Reply Date: 2022/06/28

More Info

Women with IgA nephropathy can potentially have a safe pregnancy, but several factors need to be considered to ensure both maternal and fetal health. IgA nephropathy, characterized by the deposition of IgA antibodies in the kidneys, can lead to varying degrees of kidney function impairment. However, in your case, since your kidney function is stable, with no proteinuria or hematuria, and your renal function is normal, the outlook for pregnancy is generally positive.

Pregnancy places additional demands on the body, particularly the kidneys, as they must handle increased blood volume and metabolic waste. Therefore, it is crucial to have a thorough evaluation by your nephrologist and obstetrician before attempting to conceive. They will assess your overall health, kidney function (including glomerular filtration rate), and any potential risks associated with pregnancy. If your kidney function remains stable, and you are under proper medical supervision, the risks can be minimized.

Regarding your concern about the medications you are currently taking, specifically Pentoxifylline, it is essential to discuss this with your healthcare provider. Pentoxifylline is generally considered safe during pregnancy, but the decision to continue or discontinue any medication should be made in consultation with your physician, who can weigh the benefits against any potential risks.

As for the long-term use of medications in patients with IgA nephropathy, it varies based on individual circumstances. Some patients may require ongoing treatment to manage their condition, while others may not need long-term medication if their disease is stable. Regular follow-ups with your nephrologist will help determine the best course of action for your specific situation.

In summary, while women with IgA nephropathy can conceive and have a healthy pregnancy, it is vital to have a comprehensive evaluation and ongoing monitoring throughout the pregnancy. Your healthcare team will provide guidance tailored to your health status, ensuring both you and your future child remain healthy. Always communicate openly with your doctors about your plans for pregnancy and any concerns you may have regarding your medications and overall health.

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