Is It Safe to Get the HPV Vaccine Second Dose Early? - Family Medicine

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Is there any issue with administering the second dose of the HPV vaccine earlier than scheduled?


Hello, doctor.
I received the first dose of the HPV nine-valent vaccine on June 2nd, and this morning I went to get the second dose.
However, I realized that I administered it a whole month earlier than scheduled.
I would like to know if the vaccine is still effective, whether I need to get re-vaccinated, and if there will be any issues with my body.
When can I receive the third dose?

Youzi, 30~39 year old female. Ask Date: 2022/07/04

Dr. Lin Zhebin reply Family Medicine


Hello: The vaccination schedule for the HPV nine-valent vaccine consists of three doses administered at 0 months, 2 months, and 6 months.
Since you received your first dose on June 2, the second dose should be administered after August 2, and the third dose should be administered after December 2.
Although you received your second dose early on July 4, which will not cause any harm to your body, it may potentially reduce the vaccine's effectiveness.
Therefore, it is important to receive the third dose to enhance the generation of antibodies in your body.
It is recommended that the timing for your third dose meets the following two conditions: (1) it should be administered 6-12 months after the first dose, and (2) it should be administered 4-12 months after the second dose.
Based on this, the most appropriate time for your third dose would be between December 2 of this year and June 2 of next year.

Reply Date: 2022/07/04

More Info


Getting the HPV vaccine is an important step in preventing certain types of cancers, particularly cervical cancer, which is caused by human papillomavirus (HPV). The HPV vaccine series typically consists of three doses, with specific intervals recommended between each dose to ensure optimal immune response. The standard schedule for the nine-valent HPV vaccine is as follows: the first dose is given at month zero, the second dose at 2 months, and the third dose at 6 months after the first dose.

In your case, you received the first dose on June 2 and then received the second dose a month early on July 4. While it is understandable to be concerned about the timing of your vaccinations, receiving the second dose early is generally not harmful. The primary concern with early vaccination is that it may potentially affect the immune response, which could lead to a less effective vaccine outcome. However, it does not mean that the vaccine will be ineffective or that you will need to restart the series.

The Centers for Disease Control and Prevention (CDC) and other health authorities recommend that if a dose of the HPV vaccine is administered earlier than the recommended interval, it does not need to be repeated, as long as it is within the acceptable time frame. In your case, since you received the second dose one month early, you should still be protected, but it is crucial to ensure that you complete the series as recommended.

For your third dose, the timing is also important. The CDC guidelines suggest that the third dose should be administered at least 12 weeks after the second dose and 24 weeks after the first dose. Given your situation, you should aim to receive your third dose between December 2 and June 2 of the following year. This will ensure that you meet the minimum interval requirements and maximize your immune response.

In terms of safety, receiving the HPV vaccine has been shown to be safe and effective. Common side effects include pain at the injection site, mild fever, and fatigue, but serious side effects are rare. It is also important to note that the HPV vaccine does not treat existing HPV infections or related diseases, so if you have concerns about potential exposure or infection, it may be beneficial to discuss HPV testing with your healthcare provider.

In conclusion, while receiving the second dose of the HPV vaccine early is not ideal, it is not likely to cause any significant issues. You should continue with the vaccination schedule and ensure that you receive your third dose within the recommended time frame. If you have any further concerns or questions, it is always best to consult with your healthcare provider for personalized advice and guidance. They can provide you with the most accurate information based on your health history and current situation.

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