Impact of Medication During Early Pregnancy: What You Need to Know - Pharmacology

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Took controlled medication for three weeks during the third month of pregnancy?


Hello, doctor.
I experienced bleeding in the early stages of my pregnancy, so I didn't realize I was pregnant until about 9 weeks along.
During that time, I took Lzapline 50 mg, Anxiedin 0.5 mg, Zolon 7.5 mg, and Mesyrel 50 mg.
I would like to know what the impact on the fetus might be and what tests I should undergo if I decide to continue the pregnancy.
Thank you for your help, doctor.

Nora, 10~19 year old female. Ask Date: 2022/07/13

Dr. Huang Shenggang reply Pharmacology


Hello Ms.
Nora: First, thank you for your question.
Medications during pregnancy are classified into five categories.
Below are the classifications for medications used by pregnant women:
A - No evidence of risk in the first trimester of pregnancy.

B - Animal studies show no harm, but there is a lack of sufficient data in pregnant women.

C - Animal studies show harm, but there is a lack of well-controlled studies in pregnant women.

D - There is evidence of risk to the human fetus, but it may be used in life-threatening situations.

X - There is evidence of risk to the human fetus, and the risks clearly outweigh the benefits.
It is absolutely contraindicated in pregnant women.

1.
Lzapline is classified as Category B.

2.
Anxiedin is classified as Category C.

3.
Zolon could not be found in the database.

4.
Mesyrel is classified as Category C.

Taking the above medications is generally acceptable; however, it is advisable to consult an obstetrician when considering medication during pregnancy.

Reply Date: 2022/07/13

More Info


The impact of medication during early pregnancy is a significant concern for many expectant mothers, especially when they are unaware of their pregnancy status while taking certain medications. In your case, you mentioned taking several medications, including Lzapline (50 mg), Anxiedin (0.5 mg), Zolon (7.5 mg), and Mesyrel (50 mg) around the 9-week mark of your pregnancy. Understanding the potential effects of these medications on fetal development is crucial.

First, it's important to note that the first trimester of pregnancy, particularly the first 12 weeks, is a critical period for fetal development. During this time, the foundations for major organs and systems are established. Therefore, exposure to certain medications can potentially lead to adverse effects, including congenital anomalies or developmental issues.


Medication Categories and Their Impacts
1. Lzapline (likely a form of an antipsychotic): Medications in this category can have varying effects. Some studies suggest that certain antipsychotics may be associated with risks such as low birth weight or withdrawal symptoms in newborns. However, the specific effects can depend on the type of medication and the dosage.

2. Anxiedin (an anxiolytic): Similar to Lzapline, anxiolytics can pose risks during pregnancy. Some studies indicate that benzodiazepines, a common class of anxiolytics, may be linked to an increased risk of cleft lip and palate when taken during the first trimester.
3. Zolon (likely a form of a steroid): Corticosteroids can be prescribed for various conditions, but their use during pregnancy should be closely monitored. While they can be necessary for managing certain health issues, they may also have implications for fetal growth and development.

4. Mesyrel (likely a form of an antidepressant): Antidepressants can also have varying effects during pregnancy. Some studies have shown associations with risks such as pulmonary hypertension in newborns, while others suggest that untreated maternal depression can pose greater risks to both the mother and the baby.


Recommendations for Monitoring and Care
Given your situation, it is essential to consult with your healthcare provider, preferably an obstetrician or a maternal-fetal medicine specialist. They can provide personalized advice based on your medical history, the specific medications you have taken, and your current health status. Here are some steps you may consider:
1. Ultrasound Examination: An ultrasound can help assess the development of the fetus and check for any abnormalities. This is typically done in the first trimester and can provide valuable information about the pregnancy's progress.

2. Blood Tests: Routine blood tests can help monitor your overall health and check for any potential issues that may arise from medication use.

3. Genetic Counseling: If there are concerns about potential congenital anomalies, genetic counseling may be beneficial. This can provide insights into risks and help you make informed decisions.

4. Regular Prenatal Care: Establishing a routine with your healthcare provider for prenatal visits is crucial. Regular check-ups will allow for ongoing monitoring of both your health and the baby's development.

5. Discuss Medication Management: If you are currently on any medications, discuss with your doctor the possibility of adjusting your treatment plan to ensure the safety of both you and your baby.


Conclusion
While the medications you mentioned may carry some risks, it is essential to approach this situation with a comprehensive plan involving your healthcare provider. They can help you navigate the complexities of medication use during pregnancy and ensure that you receive the necessary care and support. Remember, the health and well-being of both you and your baby are the top priorities, and open communication with your healthcare team is key to achieving that.

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