Pregnancy Chances with Irregular Ovulation and PCOS - Obstetrics and Gynecology

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Hello doctor, I would like to ask a question.
My girlfriend has polycystic ovary syndrome, so her menstrual cycle and ovulation are irregular.
Her last menstrual period started on June 10 and was expected to end around June 16.
We had intercourse during the two weeks after her period, but why did a pregnancy test on July 12 show negative? We also had intercourse on July 11.
When we visited the gynecologist on July 18, we confirmed the pregnancy, and by that time, her period was already seven days late.
Is it possible for her to have become pregnant between July 11 and July 18?

Niming, 20~29 year old female. Ask Date: 2022/07/21

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it should not be those 8 days; it might be about a week earlier.
Wishing you good health.

Reply Date: 2022/07/21

More Info


Understanding the complexities of pregnancy, especially in the context of Polycystic Ovary Syndrome (PCOS) and irregular ovulation, can be quite challenging. Your girlfriend's situation, characterized by irregular menstrual cycles and ovulation, is common among women with PCOS. This condition can significantly affect fertility, making it more difficult to predict ovulation and, consequently, the optimal timing for conception.

In your case, the timeline you provided indicates that your girlfriend's last menstrual period (LMP) was on June 10, and you had intercourse during the two weeks following that. If her cycles are irregular, it can be difficult to determine when ovulation occurs. Typically, ovulation occurs about 14 days before the start of the next menstrual period, but this can vary widely in women with PCOS.
Given that she had a positive pregnancy test on July 18, which was seven days after her expected period, it is indeed possible that conception occurred between July 11 and July 18. Sperm can survive in the female reproductive tract for up to five days, so if you had intercourse on July 11, and she ovulated shortly thereafter, it could lead to a successful conception.
It's important to note that women with PCOS may experience anovulation (the absence of ovulation) or irregular ovulation, which can make it harder to conceive. However, many women with PCOS can and do become pregnant, especially with appropriate medical management.
Here are some additional considerations that may help improve the chances of conception for women with PCOS:
1. Regular Monitoring: Keeping track of menstrual cycles and using ovulation predictor kits can help identify ovulation more accurately. This can be particularly useful for women with irregular cycles.

2. Lifestyle Modifications: Weight management through diet and exercise can improve insulin sensitivity and may help regulate menstrual cycles and ovulation. Even a modest weight loss can enhance fertility in women with PCOS.

3. Medical Interventions: If natural conception proves difficult, medications such as Clomiphene Citrate (Clomid) or Letrozole can be prescribed to induce ovulation. In some cases, Metformin, a medication used to treat insulin resistance, may also be beneficial.

4. Consultation with a Specialist: Working with a reproductive endocrinologist can provide tailored treatment options based on individual circumstances. They can offer guidance on the best approaches to manage PCOS and enhance fertility.

5. Emotional Support: The journey to conception can be emotionally taxing, especially with the challenges posed by PCOS. Seeking support from counseling or support groups can be beneficial.

In summary, while irregular ovulation due to PCOS can complicate conception, it is certainly possible to achieve pregnancy. The timing of intercourse, as you noted, can align with ovulation even if cycles are irregular. If you and your girlfriend continue to face challenges, consider consulting a healthcare provider who specializes in fertility to explore further options and support.

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