Male Infertility: Essential Steps for Diagnosis and Treatment - Urology

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Infertility


Hello, Dr.
Hsu: I have been married for over four years.
Three years ago and recently, I underwent two semen analyses, both showing "no sperm present." Dr.
Luo from the Department of Obstetrics and Gynecology referred me to the Department of Obstetrics and Gynecology at National Taiwan University, but they advised me to see a urologist for a testicular biopsy due to the absence of sperm in the semen analysis.
My blood test results showed LH 3.01, FSH 4.62, and Testosterone 7.03.
I would like to know: since National Taiwan University is too far, can I get a more detailed examination at a nearby provincial hospital? 1.
Should I make an appointment directly? Which specialist should I see? 2.
Are the series of tests covered by health insurance? If not, how much would it approximately cost? 3.
Should I bring my test results when I see the doctor? Thank you for taking the time to reply, thank you!!!!

Mr. Wang, 30~39 year old female. Ask Date: 2003/09/16

Dr. Xu Weikai reply Urology


Azoospermia generally requires consideration of: 1.
Obstruction of the vas deferens or ejaculatory duct.
2.
Undeveloped testes.
3.
Abnormal hormone levels or endocrine issues, as well as other factors.
Based on your report indicating low male hormone levels, I recommend the following: 1.
Assess the size and elasticity of the testes.
2.
If the appearance of the testes is normal, it may be obstructive, and tests such as a vasography should be conducted to check for patency.
3.
If the testes are very small or extremely soft with no elasticity, this may indicate testicular hypoplasia.
The causes of hypoplasia can be complex, potentially involving congenital abnormalities, chromosomal or genetic issues; it may also be acquired due to hormonal imbalances, medications, infections, etc., leading to testicular atrophy.
To determine the cause, a testicular biopsy is an effective method to identify the reason for atrophy; however, it is generally not helpful for your specific condition (azoospermia).
In other words, a testicular biopsy can only reveal the pathogenic cause (the biopsy process may further damage the testes) and does not significantly aid your fertility issues.
The only beneficial scenario is if viable spermatogenic cells can be extracted during the biopsy (if found) for culture, which may be used later for artificial insemination or other assisted reproductive techniques when the timing is appropriate.
I am not sure if anyone in the country is performing this; you might inquire at medical centers like National Taiwan University Hospital or Veterans General Hospital.
Additionally, ultrasound examination can serve as a structural reference.
Regarding the costs of the aforementioned tests, the National Health Insurance typically does not cover infertility treatments; therefore, you may need to pay out of pocket.
Of course, practices and costs can vary significantly between hospitals.
I am unaware of Mr.
Wang's location and cannot recommend a specialist; however, at National Taiwan University Hospital, you can consult Dr.
Chang Hong-Jiang.
Bringing your existing data can help reduce the time spent on redundant tests.

Reply Date: 2003/09/16

More Info


Understanding male infertility is a multifaceted process that requires careful diagnosis and treatment. Based on your situation, it is crucial to address several key aspects of male infertility, particularly in the context of your semen analysis results indicating "no sperm present" (azoospermia).

Diagnosis Steps
1. Semen Analysis: The first step in diagnosing male infertility typically involves a semen analysis, which you have already undergone. This test assesses sperm count, motility, morphology, and other parameters. In your case, the absence of sperm suggests a need for further investigation.

2. Hormonal Evaluation: The blood tests you mentioned (LH, FSH, and testosterone levels) are essential in understanding the hormonal balance that regulates sperm production. Elevated or low levels of these hormones can indicate issues with the pituitary gland or testicular function.

3. Testicular Biopsy: A testicular biopsy is often recommended when semen analysis shows no sperm. This procedure can help determine whether sperm production is occurring in the testes but not being released into the semen (obstructive azoospermia) or if there is a failure in sperm production (non-obstructive azoospermia).

4. Genetic Testing: In some cases, genetic testing may be warranted to identify chromosomal abnormalities or genetic conditions that could affect fertility, such as Klinefelter syndrome or Y chromosome microdeletions.

5. Imaging Studies: An ultrasound of the scrotum may be performed to check for structural abnormalities, such as varicoceles or obstructions in the reproductive tract.


Treatment Options
Once a diagnosis is established, treatment options can vary based on the underlying cause:
- Hormonal Therapy: If hormonal imbalances are identified, medications may be prescribed to correct these levels, potentially improving sperm production.

- Surgical Interventions: In cases of obstructive azoospermia, surgical procedures may be performed to remove blockages or repair the reproductive tract.

- Assisted Reproductive Technologies (ART): If sperm production is present but not in the ejaculate, techniques like sperm retrieval (TESE or TESA) followed by IVF or ICSI (intracytoplasmic sperm injection) may be utilized.

- Lifestyle Modifications: Addressing lifestyle factors such as smoking, alcohol consumption, and obesity can also improve fertility outcomes.


Practical Steps for Your Situation
1. Consultation: You can directly schedule an appointment with a urologist specializing in male infertility at your local hospital. It is advisable to ask for a urologist or a reproductive endocrinologist.

2. Insurance Coverage: Inquire with your health insurance provider regarding coverage for fertility evaluations and treatments. Many tests and procedures may be covered, but this can vary widely by plan.

3. Documentation: Bring all previous test results and medical records to your appointment. This information will help the physician understand your history and guide further testing or treatment.

4. Follow-Up: After initial consultations and tests, follow up with your healthcare provider to discuss results and next steps. It may take time to find the right approach, so patience and open communication with your medical team are essential.


Conclusion
Male infertility can be a complex issue, but with the right diagnostic approach and treatment plan, many men can achieve successful outcomes. It is crucial to work closely with healthcare professionals who specialize in this area to navigate the challenges effectively. Remember, you are not alone in this journey, and there are various options available to help you realize your goal of fatherhood.

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